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1. Introduction
2. Outline
3. History of the science of immunology
4. Two theories of immunity
5. Initiation of antibody responses in tissue culture
6. Identification and purification of mouse DCs
7. Zanvil A. Cohn and Ralph M. Steinman
8. The first recognized function of dendritic cells
9. The mixed leukocyte reaction in vitro
10. The initiation of transplant rejection in vivo
11. Peter Medawar and James L. Gowans
12. Features of T cell responses initiated by DCs
13. T helper-dependent antibody production
14. Formation of cytotoxic T lymphocytes (CTL)
15. Microenvironment for generating immunity
16. DCs: "nature's adjuvants" for T cell immunity
17. Initiating immunity or "immunogenicity"
18. First investigators of antigen presentation by DCs
19. Features of innate vs. adaptive immunity
20. Dendritic cells and innate immunity
21. How DCs facilitate innate and adaptive immunity
22. Some locations for antigen capturing DCs
23. Dendritic cells within airway epithelium
24. Diagram of a lymph node
25. DCs in T cell areas of mouse lymph node
26. DC in T cell area of peripheral lymphoid organs
27. Modern approach for detecting DCs in T cells area
28. Visualizing DCs in vivo, also in intact living tissues
29. DCs' antigen capture, processing and presentation
30. Targeting of anti-langerin/CD207 to DCs in vivo
31. Delivering a protein to dendritic cells in vivo
32. Monitoring uptake, processing and presentation
33. Example: antibody-targeted ovalbumin
34. Example: antibody-targeted LACK
35. Anti-DEC-HIV-gag as an AIDS vaccine
36. Cross presentation of antigens by dendritic cells
37. Antigen handling by DCs: current concepts
38. Maturation of dendritic cells
39. Some stimuli and components of DC maturation
40. Pattern recognition receptors in dendritic cells
41. Changes in cell surface markers during maturation
42. Example: LACK delivery via DEC-205 w. adjuvant
43. Dendritic cell maturation - summary
44. Some subsets of dendritic cells in steady state
45. Dendritic cells (Langerhans cells) in epidermis
46. Langerhans cells after maturation
47. Nikolaus Romani and Gerold Schuler
48. Induction of antigen-specific peripheral tolerance
49. Capture of antigens by DCs in steady state
50. Iduction of tolerance vs. immunity by DCs
51. Controlling antigen-specific tolerance in vivo
52. Putting the features of dendritic cells together
53. The bright future of immunology in human disease
54. DCs and disease-related immunity
55. Autoimmune and autoinflammatory diseases
56. TNF in psoriatic skin is expressed in CD11c+ cells
57. Dendritic cells and new vaccines
58. Vaccines-related, important goal for immunology
59. Histrory of vaccines
60. Medicine needs new vaccine success stories
61. Vaccines: interface of immunology and medicine
62. Harnessing DCs for control of the immune system
63. Ex vivo generation of antigen-bearing DCs
64. Ex vivo generation of highly enriched human DCs
65. Ex vivo dendritic cells for cancer research
66. Collaborative research, stimulating vaccine science
67. Combining antigens delivery and maturation stimuli
68. Example: response to combined vaccine in mouse
69. DEC-205/CD205 expression on DCs
70. Obstacles to anti-DEC-HIV protein vaccines
71. A proposal
72. New cell type within the elegant immune orchestra
73. Energizing the clonal selection theory of immunity
74. Macfarlane Burnet
75. Overcoming the hurdles to control T cell function
76. The many interfaces of immunology and medicine
77. Principles and approaches to vaccines
78. Sources of support for the research
79. Thanks to former and current PI's in the lab

Topics Covered

• Identification of a new cell type
• Initiating immunity
• Features of dendritic cells
• Interfaces with medicine
• New approaches to vaccine

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Steinman, R. (2009, May 31). Dendritic cells: linking innate to different forms of adaptive immunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/1288/.
Export Citation (RIS)

Publication History

• Published on May 31, 2009

Financial Disclosures

• Prof. Ralph Steinman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.