• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Significant figures in macrophage research
3. Human diseases of innate immunity
4. Macrophages in innate immunity
5. Talk outline
6. Differentiation and distribution of macrophages
7. The EGF-TM7 family
8. Macrophages remodel tissues in development
9. Kupffer cells F4/80+
10. Resident tissue macrophages' microheterogeneity
11. Differentiation of monocytes
12. F4/80+ Langerhans cell in normal skin
13. Differentiation of microglia
14. Trophic interaction: haematopoiesis
15. Haematopoietic stroma
16. F4/80 in red pulp spleen
17. Sialoadhesin in marginal zone of spleen
18. Marginal zone
19. Monocyte recruitment
20. Experimental models: sterile mouse peritonitis
21. BCG granulomata
22. Lysozyme expression in activated macrophages
23. Monocyte heterogeneity and recruitment
24. Differential activation of macrophages
25. Phagocytosis of apoptotic thymocyte
26. Antibody coated erythrocytes (EIgG)
27. Phagocytic pathway
28. APC pattern recognition receptors
29. APC receptors
30. Sensors of pattern recognition
31. Macrophage receptors
32. Macrophage interactions
33. Dectin-1
34. Dectin-1 recognises beta 1-3/6 linked glucans
35. Zymosan induced TNF-alpha production
36. Dectin-1 tail is required for cytokine secretion
37. Dectin-1 ITAM like motif is required for ingestion
38. Dectin-1 collaborates with TLR in signalling
39. Fungal walls are rich in beta glucan
40. Uptake of C. albicans by macrophages
41. Candida infection in dectin-1-deficient mice
42. Mannose receptor (MR): overview
43. Mannose receptor
44. Reagents used in search for MR ligands
45. CRD4-7Fc recognises ligands in secretory organs
46. Ligands for the cysteine-rich domain of the MR
47. The sMR-mediated Ag delivery hypothesis
48. A subset of Met macrophages express CR-ligands
49. CR-ligand+ cells migrate in response to LPS
50. LPS increases the humoral response
51. Scavenger receptors
52. Scavenger receptor A
53. Meningococcal septicaemia, haemorrhagic rash
54. Neisseria meningitidis (NM)
55. SR-A and Neisseria meningitidis
56. Uptake of NM is uncoupled from TNF production
57. Scavenger receptor A and NM
58. SR-A protects against NM
59. MARCO in a marker of activated macrophage
60. Binding of NM
61. Role of NM, INF-gamma in MARCO expression
62. Receptor collaboration
63. Plasma membrane in macrophage functions
64. EGF-TM7 family functions
65. Activatory and inhibitory receptor pairs
66. Macrophage fusion
67. Quantitation of macrophage fusion
68. Isolation of antibodies
69. Model of IL-4 induced macrophage fusion
70. Functional significance of macrophage fusion
71. Summary: macrophages in innate immunity
72. Thanks
73. References

Topics Covered

• Differentiation and distribution of macrophages
• The EGF-TM7 family
• Differentiation of monocytes
• Tropic interactions
• Monocyte recruitment
• Immune activation
• Monocyte heterogeneity
• Differential activation of macrophage
• Phagocytic pathway
• APC pattern recognition receptors
• APC receptors
• Macrophage receptors and interactions
• Dectin-1
• Mannose receptor
• MR ligands
• Scavenger receptors
• Neisseria Meningitidis
• Receptor collaboration
• Plasma membrane modulation of macrophage functions
• Activatory and inhibitory receptor pairs
• Macrophage fusion
• Isolation of antibodies

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 31, 2009
• Archived on October 16, 2017

Financial Disclosures

• Siamon Gordon recieves Honoraria from Verseau Therapeutics and Myeloid Therapeutics. He has recieveid royalties from Thermo Fisher Scientific, and is involved in Bio-Rad sales.