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- Co-ordination of G1 Progression
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1. START control in yeast
- Prof. Curt Wittenberg
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2. The pRB/E2F pathway
- Prof. Jacqueline Lees
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3. Cell cycle control by the ubiquitin system in mammals
- Prof. Michele Pagano
- Chromosome Duplication
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4. Replication licensing
- Prof. Julian Blow
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5. Initiation of DNA replication
- Prof. Bruce Stillman
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6. Regulation of replication fork progression and stability
- Dr. Luis Aragón
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7. Nucleosome assembly during DNA replication
- Dr. Alain Verreault
- Preparing for Mitosis
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8. Sister chromatid cohesion: simple concept, complex reality
- Prof. Douglas Koshland
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9. Mitotic chromosome condensation
- Prof. Andrew Belmont
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10. Centrosome duplication and separation in animal cells
- Prof. Andrew Fry
- Spindle Assembly and Chromosome Segregation
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11. Bipolar spindle assembly
- Dr. Eric Karsenti
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12. Chromosome bi-orientation in yeast
- Prof. Mike Stark
- Prof. Tomo Tanaka
- Mitotic Exit and Cytokinesis
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14. Cleavage furrow formation and ingression during animal cytokinesis
- Dr. Pier Paolo D'Avino
- Checkpoints Governing Cell Cycle Progression
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15. The DNA damage response
- Dr. Vincenzo Costanzo
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16. The spindle checkpoint
- Dr. Kevin Hardwick
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17. Spindle movement and checkpoint control during mitosis in yeast
- Prof. John Cooper
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18. The G2/M transition
- Prof. Dr. René Medema
- The Cell Cycle in Development and Cancer
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19. Mouse models to investigate cell cycle and cancer
- Dr. Philipp Kaldis
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20. Cell cycle: a complex network of signals regulating cell proliferation
- Prof. Antonio Giordano
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21. Drug discovery and target validation in the p53 pathway
- Prof. Sir David Lane
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22. Role and regulation of Cdk inhibitors in development and cancer
- Prof. Martine Roussel
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24. The Myc transcription factor network
- Prof. Robert N. Eisenman
- Meiosis: A Specialized Cell Cycle
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25. Recombination and the formation of chiasmata in meiosis
- Prof. Matthew Whitby
- Archived Lectures *These may not cover the latest advances in the field
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26. Geometric regulation of kinetochore orientation
- Prof. Yoshinori Watanabe
Printable Handouts
Navigable Slide Index
- Introduction
- The Metazoan life cycle
- Meiosis versus Mitosis
- Mitotic chromosome segregation
- Differences between mitosis and meiosis
- Overview of talk
- Homologous recombination
- Meiotic prophase I
- DSB repair model (Szostak et al., 1983)
- Detection of meiotic recombination intermediates
- Detection of SEIs and dHJs
- Non-crossovers are probably formed by SDSA
- sHJs give rise to crossovers in S. pombe
- Chiasmata link the homologues by cohesin
- Programmed DSBs during meiosis
- DSB formation does not only depend on Spo11
- DSB formation restricted to leptotene, prophase I
- DSB can be uncoupled from DNA replication
- Mer2 is phosphorylated at multiple sites
- Mer2 phosphorylation is essential
- Mer2 phosphorylation and DNA replication
- Processing the DSB (1)
- Structure of the MRX/N complex
- Processing the DSB (2)
- Pairing of homologous DNAs and strand invasion
- How do Rad51 and Dmc1 function together?
- Other factors needed for homologous pairing
- Assembly of the Rad51/Dmc1 filament
- Simple model for the aid of accessory proteins
- Resolving HJ and crossover formation
- The ZMM proteins and Class I crossovers
- Mer3 and Msh4-Msh5
- The synaptonemal complex
- The nucleation of Zip1 polymerization
- Class I crossovers need specific resolution of dHJ
- Class II crossovers depend on Mus81-Eme1/Mms4
- Conclusion
- Reference
Topics Covered
- The metazoan life cycle
- Meiosis vs. mitosis
- Mitotic chromosome segregation
- Models of homologous recombination and how it generates chiasmata
- Initiation of homologous recombination by programmed DNA double-strand breaks
- Mechanisms of double-strand break repair
- Mechanisms of crossover formation
Links
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Talk Citation
Whitby, M. (2009, April 30). Recombination and the formation of chiasmata in meiosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/1274/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Matthew Whitby has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.