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- Co-ordination of G1 Progression
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1. START control in yeast
- Prof. Curt Wittenberg
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2. The pRB/E2F pathway
- Prof. Jacqueline Lees
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3. Cell cycle control by the ubiquitin system in mammals
- Prof. Michele Pagano
- Chromosome Duplication
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4. Replication licensing
- Prof. Julian Blow
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5. Initiation of DNA replication
- Prof. Bruce Stillman
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6. Regulation of replication fork progression and stability
- Dr. Luis Aragón
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7. Nucleosome assembly during DNA replication
- Dr. Alain Verreault
- Preparing for Mitosis
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8. Sister chromatid cohesion: simple concept, complex reality
- Prof. Douglas Koshland
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9. Mitotic chromosome condensation
- Prof. Andrew Belmont
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10. Centrosome duplication and separation in animal cells
- Prof. Andrew Fry
- Spindle Assembly and Chromosome Segregation
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11. Bipolar spindle assembly
- Dr. Eric Karsenti
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12. Chromosome bi-orientation in yeast
- Prof. Mike Stark
- Prof. Tomo Tanaka
- Mitotic Exit and Cytokinesis
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14. Cleavage furrow formation and ingression during animal cytokinesis
- Dr. Pier Paolo D'Avino
- Checkpoints Governing Cell Cycle Progression
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15. The DNA damage response
- Dr. Vincenzo Costanzo
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16. The spindle checkpoint
- Dr. Kevin Hardwick
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17. Spindle movement and checkpoint control during mitosis in yeast
- Prof. John Cooper
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18. The G2/M transition
- Prof. Dr. René Medema
- The Cell Cycle in Development and Cancer
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19. Mouse models to investigate cell cycle and cancer
- Dr. Philipp Kaldis
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20. Cell cycle: a complex network of signals regulating cell proliferation
- Prof. Antonio Giordano
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21. Drug discovery and target validation in the p53 pathway
- Prof. Sir David Lane
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22. Role and regulation of Cdk inhibitors in development and cancer
- Prof. Martine Roussel
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24. The Myc transcription factor network
- Prof. Robert N. Eisenman
- Meiosis: A Specialized Cell Cycle
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25. Recombination and the formation of chiasmata in meiosis
- Prof. Matthew Whitby
- Archived Lectures *These may not cover the latest advances in the field
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26. Geometric regulation of kinetochore orientation
- Prof. Yoshinori Watanabe
Printable Handouts
Navigable Slide Index
- Introduction
- The cell cycle
- Somatic cell cycles
- Negative regulation of G1 progression by Cdk
- The "Rb pathway" in human cancer
- Two groups of Ink4 proteins
- Two groups of CIP/KIP proteins
- Expression of INK4 genes during embryogenesis
- Expression of Ink4 genes in tissues of young mice
- Testicular atrophy, fertility in Ink4d-null male mice
- Ink4c/Ink4d double deficient male mice are sterile
- Conclusion (1)
- Role of Cdk inhibitors in the CNS (1)
- Hypothesis (1)
- Role of Cdk inhibitors in the CNS (2)
- Sensory hair cell loss in Ink4d -/- mice, deafness
- Ink4d and postmitotic state of sensory hair cells
- Postnatal development in Ink4d, Kip1-null mice
- Conclusions (2)
- Role of the Rb pathway in cerebellar development
- Medulloblastoma
- Childhood medulloblastoma
- Cerebellum - little brain
- Postnatal cerebellar development
- Cerebellar development in the mouse
- The SHH/PATCHED signaling pathway
- Rb-dependent cell cycle exit and differentiation
- Ink4c expression in the mouse cerebellum
- p27Kip1 expression in the IGL
- N-Myc in GNP proliferation
- Partial rescue in adult cerebellum
- Hypothesis (2)
- Mice lacking Ink4c, p53 develop medulloblastoma
- Ink4c loss increases medulloblastoma
- p18INK4C and human medulloblastoma
- p18Ink4C/CDKN2C expression in medulloblastoma
- Conclusions (3)
- Phenotype of Ink4d- or Ink4c- deficient mice
- Acknowledgments
Topics Covered
- Somatic cell cycle
- Rb pathway
- Positive regulation of G1 phase by phosphorylation of the retinoblastoma protein (Rb) by cyclin-dependent kinases (Cdks)
- Negative regulation of G1 by Cdk-inhibitory proteins (CKIs)
- Rb pathway is often disrupted in cancers
- Two families of CKIs, differential expression in embryogenesis and adult mouse tissues
- Loss of p18Ink4c and p19ink4d induces male sterility
- Loss of p19Ink4d induces progressive deafness after birth
- Loss of p19Ink4d and p27Kip1 induces re-entry of differentiated postmitotic neurons in cycle after birth
- Loss of Ink4c and Patched or p53 induces medulloblastoma, a pediatric tumor of the cerebellum
- CKIs are required for exit from and maintenance of cell cycle exit, or quiescence, a reversible state
- Loss of CKIs leads to sterility, deafness and cancers
Links
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Talk Citation
Roussel, M. (2009, April 30). Role and regulation of Cdk inhibitors in development and cancer [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/1272/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Martine Roussel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.