• Co-ordination of G1 Progression
• 37 min
  1. START control in yeast

  • Prof. Curt Wittenberg
• 33 min
  2. The pRB/E2F pathway

  • Prof. Jacqueline Lees
• 35 min
  3. Cell cycle control by the ubiquitin system in mammals

  • Prof. Michele Pagano
• Chromosome Duplication
• 47 min
  4. Replication licensing

  • Prof. Julian Blow
• 51 min
  5. Initiation of DNA replication

  • Prof. Bruce Stillman
• 48 min
  6. Regulation of replication fork progression and stability

  • Dr. Luis Aragón
• 35 min
  7. Nucleosome assembly during DNA replication

  • Dr. Alain Verreault
• Preparing for Mitosis
• 27 min
  8. Sister chromatid cohesion: simple concept, complex reality

  • Prof. Douglas Koshland
• 50 min
  9. Mitotic chromosome condensation

  • Prof. Andrew Belmont
• 33 min
  10. Centrosome duplication and separation in animal cells

  • Prof. Andrew Fry
• Spindle Assembly and Chromosome Segregation
• 30 min
  11. Bipolar spindle assembly

  • Dr. Eric Karsenti
• 54 min
  12. Chromosome bi-orientation in yeast

  • Prof. Mike Stark
  • Prof. Tomo Tanaka
• 43 min
  13. Regulation of mammalian cell division by the chromosomal passenger complex

  • Dr. Susanne Lens
• Mitotic Exit and Cytokinesis
• 39 min
  14. Cleavage furrow formation and ingression during animal cytokinesis

  • Dr. Pier Paolo D'Avino
• Checkpoints Governing Cell Cycle Progression
• 34 min
  15. The DNA damage response

  • Dr. Vincenzo Costanzo
• 54 min
  16. The spindle checkpoint

  • Dr. Kevin Hardwick
• 27 min
  17. Spindle movement and checkpoint control during mitosis in yeast

  • Prof. John Cooper
• 43 min
  18. The G2/M transition

  • Prof. Dr. René Medema
• The Cell Cycle in Development and Cancer
• 62 min
  19. Mouse models to investigate cell cycle and cancer

  • Dr. Philipp Kaldis
• 18 min
  20. Cell cycle: a complex network of signals regulating cell proliferation

  • Prof. Antonio Giordano
• 40 min
  21. Drug discovery and target validation in the p53 pathway

  • Prof. Sir David Lane
• 30 min
  22. Role and regulation of Cdk inhibitors in development and cancer

  • Prof. Martine Roussel
• 48 min
  23. The kinetochore as a target for the development of mitosis specific anti-cancer drugs

  • Dr. Tim Yen
• 47 min
  24. The Myc transcription factor network

  • Prof. Robert N. Eisenman
• Meiosis: A Specialized Cell Cycle
• 58 min
  25. Recombination and the formation of chiasmata in meiosis

  • Prof. Matthew Whitby
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  26. Geometric regulation of kinetochore orientation

  • Prof. Yoshinori Watanabe

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Chromosome structure and function
3. Smc complexes
4. EM pictures of Smc complexes
5. Soluble Smc complex structure
6. Cohesin as prototype for Smc complex function
7. Cohesin and sister chromatid cohesion
8. Kinetochore attachment - without cohesion
9. Kinetochore attachment - with cohesion
10. Cohesion as boundaries for condensation
11. Cohesin and transcription domains
12. Cohesion promotes chromosome integrity
13. Budding yeast as a model
14. Yeast chromosome structure is an oxymoron
15. Assaying cohesion in yeast by fluorescence
16. Cohesin subunits and auxiliary factors
17. Regulation of cohesin loading onto chromosomes
18. Eco1 and cell cycle regulation of cohesion
19. Eco1 and DNA damage induced cohesion
20. Why complex regulation of the cohesive state?
21. Cohesion maintenance
22. The dissolution of cohesion at anaphase onset
23. Summary of the complex regulation of cohesin
24. The embrace model for chromatin binding (1)
25. Alternate model for Smc tethering
26. Smc3 head is key regulator to convert cohesin
27. Summary of the Snap and embrace models
28. So many important questions still to be answered
29. Acknowledgments

Topics Covered

• Sister chromatid cohesion: simple concept complex reality
• Overview of higher order chromosome structure
• Smc (structural maintenance of chromosomes) complexes as mediators of higher order chromosome structure
• Introduction to cohesin, the Smc complex that mediates sister chromatid cohesion
• Biological function of cohesion
• Cohesin binding to chromatin
• Establishment, maintenance and dissolution of cohesion
• The molecular basis of cohesins as chromatid tethers

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on April 30, 2009

Financial Disclosures

• Prof. Douglas Koshland has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.