• Chromosome Duplication
• 35 min
  1. Nucleosome assembly during DNA replication

  • Dr. Alain Verreault
• Spindle Assembly and Chromosome Segregation
• 54 min
  2. Chromosome bi-orientation in yeast

  • Prof. Mike Stark
  • Prof. Tomo Tanaka
• The Cell Cycle in Development and Cancer
• 62 min
  3. Mouse models to investigate cell cycle and cancer

  • Dr. Philipp Kaldis
• 47 min
  4. The Myc transcription factor network

  • Prof. Robert N. Eisenman
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  5. Geometric regulation of kinetochore orientation

  • Prof. Yoshinori Watanabe
• 54 min
  6. The spindle checkpoint

  • Dr. Kevin Hardwick
• 39 min
  7. Cleavage furrow formation and ingression during animal cytokinesis

  • Dr. Pier Paolo D'Avino
• 27 min
  8. Spindle movement and checkpoint control during mitosis in yeast

  • Prof. John Cooper
• 43 min
  9. The G2/M transition

  • Prof. Dr. René Medema
• 43 min
  10. Regulation of mammalian cell division by the chromosomal passenger complex

  • Dr. Susanne Lens
• 30 min
  11. Role and regulation of Cdk inhibitors in development and cancer

  • Prof. Martine Roussel
• 58 min
  12. Recombination and the formation of chiasmata in meiosis

  • Prof. Matthew Whitby
• 18 min
  13. Cell cycle: a complex network of signals regulating cell proliferation

  • Prof. Antonio Giordano
• 40 min
  14. Drug discovery and target validation in the p53 pathway

  • Prof. Sir David Lane
• 37 min
  15. START control in yeast

  • Prof. Curt Wittenberg
• 33 min
  16. The pRB/E2F pathway

  • Prof. Jacqueline Lees
• 35 min
  17. Cell cycle control by the ubiquitin system in mammals

  • Prof. Michele Pagano
• 47 min
  18. Replication licensing

  • Prof. Julian Blow
• 51 min
  19. Initiation of DNA replication

  • Prof. Bruce Stillman
• 48 min
  20. Regulation of replication fork progression and stability

  • Dr. Luis Aragón
• 27 min
  21. Sister chromatid cohesion: simple concept, complex reality

  • Prof. Douglas Koshland
• 50 min
  22. Mitotic chromosome condensation

  • Prof. Andrew Belmont
• 33 min
  23. Centrosome duplication and separation in animal cells

  • Prof. Andrew Fry
• 48 min
  24. The kinetochore as a target for the development of mitosis specific anti-cancer drugs

  • Dr. Tim Yen
• 34 min
  25. The DNA damage response

  • Dr. Vincenzo Costanzo
• 30 min
  26. Bipolar spindle assembly

  • Dr. Eric Karsenti

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Chromosome structure and function
3. Smc complexes
4. EM pictures of Smc complexes
5. Soluble Smc complex structure
6. Cohesin as prototype for Smc complex function
7. Cohesin and sister chromatid cohesion
8. Kinetochore attachment - without cohesion
9. Kinetochore attachment - with cohesion
10. Cohesion as boundaries for condensation
11. Cohesin and transcription domains
12. Cohesion promotes chromosome integrity
13. Budding yeast as a model
14. Yeast chromosome structure is an oxymoron
15. Assaying cohesion in yeast by fluorescence
16. Cohesin subunits and auxiliary factors
17. Regulation of cohesin loading onto chromosomes
18. Eco1 and cell cycle regulation of cohesion
19. Eco1 and DNA damage induced cohesion
20. Why complex regulation of the cohesive state?
21. Cohesion maintenance
22. The dissolution of cohesion at anaphase onset
23. Summary of the complex regulation of cohesin
24. The embrace model for chromatin binding (1)
25. Alternate model for Smc tethering
26. Smc3 head is key regulator to convert cohesin
27. Summary of the Snap and embrace models
28. So many important questions still to be answered
29. Acknowledgments

Topics Covered

• Sister chromatid cohesion: simple concept complex reality
• Overview of higher order chromosome structure
• Smc (structural maintenance of chromosomes) complexes as mediators of higher order chromosome structure
• Introduction to cohesin, the Smc complex that mediates sister chromatid cohesion
• Biological function of cohesion
• Cohesin binding to chromatin
• Establishment, maintenance and dissolution of cohesion
• The molecular basis of cohesins as chromatid tethers

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on April 30, 2009
• Archived on May 28, 2025

Financial Disclosures

• Prof. Douglas Koshland has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.