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Navigable Slide Index

1. Introduction
2. Chromosome structure and function
3. Smc complexes
4. EM pictures of Smc complexes
5. Soluble Smc complex structure
6. Cohesin as prototype for Smc complex function
7. Cohesin and sister chromatid cohesion
8. Kinetochore attachment - without cohesion
9. Kinetochore attachment - with cohesion
10. Cohesion as boundaries for condensation
11. Cohesin and transcription domains
12. Cohesion promotes chromosome integrity
13. Budding yeast as a model
14. Yeast chromosome structure is an oxymoron
15. Assaying cohesion in yeast by fluorescence
16. Cohesin subunits and auxiliary factors
17. Regulation of cohesin loading onto chromosomes
18. Eco1 and cell cycle regulation of cohesion
19. Eco1 and DNA damage induced cohesion
20. Why complex regulation of the cohesive state?
21. Cohesion maintenance
22. The dissolution of cohesion at anaphase onset
23. Summary of the complex regulation of cohesin
24. The embrace model for chromatin binding (1)
25. Alternate model for Smc tethering
26. Smc3 head is key regulator to convert cohesin
27. Summary of the Snap and embrace models
28. So many important questions still to be answered
29. Acknowledgments

Topics Covered

• Sister chromatid cohesion: simple concept complex reality
• Overview of higher order chromosome structure
• Smc (structural maintenance of chromosomes) complexes as mediators of higher order chromosome structure
• Introduction to cohesin, the Smc complex that mediates sister chromatid cohesion
• Biological function of cohesion
• Cohesin binding to chromatin
• Establishment, maintenance and dissolution of cohesion
• The molecular basis of cohesins as chromatid tethers

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology
• Genetics & Epigenetics

Talk Citation

Koshland, D. (2009, April 30). Sister chromatid cohesion: simple concept, complex reality [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/KJMS7763.
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Publication History

• Published on April 30, 2009

Financial Disclosures

• Prof. Douglas Koshland has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.