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About Biomedical Basics
Biomedical Basics are AI-generated explanations prepared with access to the complete collection, human-reviewed prior to publication. Short and simple, covering biomedical and life sciences fundamentals.
Topics Covered
- Genome structure & organization
- Chromosomes & plasmids
- Gene regulation & operons
- Horizontal gene transfer & resistance
- Studying genetic variation & evolution
- Genetic basis of antibiotic resistance
- Genomic technologies & their impact
Talk Citation
(2025, October 30). Bacterial genetics [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 30, 2025, from https://doi.org/10.69645/IISV2653.Export Citation (RIS)
Publication History
- Published on October 30, 2025
Financial Disclosures
A selection of talks on Microbiology
Transcript
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0:00
In this talk, the focus
is Bacterial Genetics,
supported by coverage
of the structure and
organization of
bacterial genomes,
including unique features of
chromosomes and plasmids;
mechanisms of gene
regulation and
adaptation, such as operons
and regulatory proteins;
processes of horizontal
gene transfer that
drive genetic diversity
and antibiotic resistance;
methods for studying genetic
variation and tracking
evolutionary changes;
and the implications
of modern genetic
technologies for research,
surveillance, and combating
antibiotic resistance..
Bacterial genetics studies
how bacteria inherit and
exchange genetic information,
crucial to their adaptability,
pathogenicity, and
antibiotic resistance.
Most have a single,
circular chromosome in
the nucleoid region—DNA
compacted by supercoiling
and nucleoid-associated proteins.
Some, like Borrelia, have
linear chromosomes
or plasmids needing
unique end replication
strategies, such
as terminal proteins
or hairpin telomeres.
Bacteria often carry plasmids—small,
extrachromosomal DNA—that
spread virulence and
resistance genes.
Understanding DNA
organization forms the basis
of research on bacterial
genetic management
and evolution.
Besides their main chromosome,
bacteria often carry plasmids
that encode genes for
antibiotic resistance,
toxins, or other
survival traits, and can
transfer between cells,
making
them key agents of
genetic change.
Bacterial genes are
commonly organized