• The Notion of Epigenetics
• 43 min
  1. Cytoplasmic epigenetics: inheritance by cytoplasmic continuity

  • Prof. Philippe Silar
  • Dr. Fabienne Malagnac
• Epigenetics: Paradigms
• 38 min
  2. The molecular mechanism of X chromosome inactivation

  • Prof. Neil Brockdorff
• 29 min
  3. Genomic imprinting: history and embryology

  • Prof. Davor Solter
• 48 min
  4. X chromosome inactivation in human cells

  • Prof. Barbara Migeon
• 41 min
  5. RNAi and heterochromatin in plants and fission yeast

  • Prof. Robert Martienssen
• Epigenetics: Mechanisms
• 23 min
  6. Polycomb epigenetic mechanisms: role of PcG complexes

  • Prof. Vincenzo Pirrotta
• 29 min
  7. Polycomb epigenetic mechanisms: methylation of DNA

  • Prof. Vincenzo Pirrotta
• 56 min
  8. Histone modifications and prospects for an epigenetic code

  • Prof. Bryan Turner
• 68 min
  9. Epigenetic control by histone methylation

  • Prof. Thomas Jenuwein
• 38 min
  10. Histone dynamics, heritability and variants

  • Dr. Genevieve Almouzni
• 51 min
  11. Gene silencing in budding yeast

  • Prof. Susan Gasser
• Epigenetics: Heritability and Reversibility
• 51 min
  12. Nuclear cloning, stem cells and epigenetic reprogramming

  • Prof. Rudolf Jaenisch
• 64 min
  13. Stem cell memory

  • Prof. James Sherley
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  14. Epigenetics: a historical overview

  • Dr. Robin Holliday
• 43 min
  15. DNA methylation

  • Prof. Adrian Bird
• 45 min
  16. DNA methylation and genome defense in Neurospora crassa

  • Prof. Eric Selker
• 34 min
  17. A historical perspective on ideas on X-chromosome inactivation

  • Dr. Mary Lyon
• 40 min
  18. Evolution of mammal epigenetic control systems

  • Prof. Jenny Graves
• 60 min
  19. Genomic imprinting and its regulation

  • Dr. Anne Ferguson-Smith
• 40 min
  20. Nuclear organization and gene expression

  • Prof. David Spector
• 39 min
  21. Germ cells

  • Prof. Azim Surani
• 41 min
  22. Epigenetic regulation of phenotype

  • Prof. Emma Whitelaw
• 68 min
  23. Epigenetically mediated gene silencing: a companion to genetic alterations in driving tumorigenesis

  • Prof. Stephen Baylin
• 36 min
  24. Cytoplasmic epigenetics: proteins acting as genes

  • Prof. Reed Wickner

Printable Handouts

PDF

Navigable Slide Index

1. Epigenetically mediated gene silencing
2. Process of DNA methylation
3. Altered chromatin status in cancer
4. Familial cancer genes
5. Chromatin composition
6. Screening the cancer genome
7. Vogalstein paradigm
8. Re-activated hypermethylated genes
9. Hypothesis-early stage epigenetic gene silencing
10. Epigenetic & genetic interaction in tumorigenesis
11. sFRP genes - what are they?
12. SFRP hypermethylation and CRC progression
13. Epigenetic silencing of SFRPs in CRC
14. Concept of cancer pathway addiction
15. Collaboration in early colon tumorigenesis
16. Heretical hypothesis
17. Re-activated hypermethylated genes
18. Screening the cancer genome
19. HIC-1 is a candidate tumor suppressor gene
20. HIC-1 hypermethylation in human cancer
21. Targeted disruption of mouse Hic-1 gene
22. Hic-1 as a tumor suppressor in mouse models
23. Epigenetic and genetic interactions
24. The full activities if HIC-1
25. Properties of SIRT1
26. Paradigm summary for HIC-1 P53 interaction
27. Hypothesis review
28. Translational implications

Topics Covered

• Introduction to epigenetic changes in cancer
• defining the process of promoter DNA hypermethylation as a constituent of a broad range of chromatin abnormalities in cancer
• defining the genes aberrantly silenced in cancer including approaches being used to screen the cancer genome for such genes
• defining what is known about the interaction of DNA methylation and chromatin modifications for initiating and maintaining gene silencing in cancer
• outlining the position of aberrant gene silencing in tumor progression and particularly highlighting the key role these changes may play for the earliest steps in tumorigenesis
• defining the potential for using DNA hypermethylated gene promoter sequences as molecular markers for cancer risk assessment, early diagnosis and prognosis
• discussing the possibilities for targeting reversal of gene silencing as a prevention and therapeutic strategy for cancer

Links

Series:

• Epigenetics

Categories:

• Biochemistry
• Cancer
• Cell Biology
• Genetics & Epigenetics

Therapeutic Areas:

• Oncology

Talk Citation

Baylin, S. (2007, October 1). Epigenetically mediated gene silencing: a companion to genetic alterations in driving tumorigenesis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 26, 2024, from https://doi.org/10.69645/VRTX2257.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on December 10, 2018

Financial Disclosures

• Prof. Stephen Baylin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.