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Biomedical Basics

Sepsis

  • Created by Henry Stewart Talks
Published on October 30, 2025   6 min

A selection of talks on Infectious Diseases

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This overview addresses Sepsis, with particular emphasis on the definition and pathophysiology of sepsis, including how the body’s immune response becomes dangerously dysregulated and leads to widespread organ dysfunction. We will discuss common causes, risk factors, clinical presentation, and the importance of early recognition. Diagnostic strategies and scoring systems will be explained, along with current evidence-based treatment approaches focusing on early intervention and multidisciplinary care. Finally, we will address ongoing challenges such as antimicrobial resistance, the long-term impact on survivors, and the need for prevention and continued research.. Sepsis is a critical medical condition and a leading cause of death globally. Although recognised for centuries, our understanding has advanced significantly in recent years. Sepsis occurs when the body’s response to infection becomes dangerously dysregulated, causing not only local tissue injury but also widespread inflammation and organ dysfunction. Various pathogens can trigger sepsis, most commonly bacteria, but also viruses, fungi, and parasites. Sepsis results from an excessive, unregulated response to infection, making it an urgent medical challenge. When an infectious agent invades the body, the immune system responds to contain and eradicate it. In sepsis, however, this response spirals out of control. Recognition of microbial molecules by receptors like Toll-like receptors

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