• The Notion of Epigenetics
• 43 min
  1. Cytoplasmic epigenetics: inheritance by cytoplasmic continuity

  • Prof. Philippe Silar
  • Dr. Fabienne Malagnac
• Epigenetics: Paradigms
• 38 min
  2. The molecular mechanism of X chromosome inactivation

  • Prof. Neil Brockdorff
• 29 min
  3. Genomic imprinting: history and embryology

  • Prof. Davor Solter
• 48 min
  4. X chromosome inactivation in human cells

  • Prof. Barbara Migeon
• 41 min
  5. RNAi and heterochromatin in plants and fission yeast

  • Prof. Robert Martienssen
• Epigenetics: Mechanisms
• 23 min
  6. Polycomb epigenetic mechanisms: role of PcG complexes

  • Prof. Vincenzo Pirrotta
• 29 min
  7. Polycomb epigenetic mechanisms: methylation of DNA

  • Prof. Vincenzo Pirrotta
• 56 min
  8. Histone modifications and prospects for an epigenetic code

  • Prof. Bryan Turner
• 68 min
  9. Epigenetic control by histone methylation

  • Prof. Thomas Jenuwein
• 38 min
  10. Histone dynamics, heritability and variants

  • Dr. Genevieve Almouzni
• 51 min
  11. Gene silencing in budding yeast

  • Prof. Susan Gasser
• Epigenetics: Heritability and Reversibility
• 51 min
  12. Nuclear cloning, stem cells and epigenetic reprogramming

  • Prof. Rudolf Jaenisch
• 64 min
  13. Stem cell memory

  • Prof. James Sherley
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  14. Epigenetics: a historical overview

  • Dr. Robin Holliday
• 43 min
  15. DNA methylation

  • Prof. Adrian Bird
• 45 min
  16. DNA methylation and genome defense in Neurospora crassa

  • Prof. Eric Selker
• 34 min
  17. A historical perspective on ideas on X-chromosome inactivation

  • Dr. Mary Lyon
• 40 min
  18. Evolution of mammal epigenetic control systems

  • Prof. Jenny Graves
• 60 min
  19. Genomic imprinting and its regulation

  • Dr. Anne Ferguson-Smith
• 40 min
  20. Nuclear organization and gene expression

  • Prof. David Spector
• 39 min
  21. Germ cells

  • Prof. Azim Surani
• 41 min
  22. Epigenetic regulation of phenotype

  • Prof. Emma Whitelaw
• 68 min
  23. Epigenetically mediated gene silencing: a companion to genetic alterations in driving tumorigenesis

  • Prof. Stephen Baylin
• 36 min
  24. Cytoplasmic epigenetics: proteins acting as genes

  • Prof. Reed Wickner

Printable Handouts

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Navigable Slide Index

1. Germ cells
2. Fertilized egg
3. Mammalian egg
4. Fertilization
5. Parental mammalian genomes - non-equivalent
6. Properties of germ cell lineage
7. Mechanisms of germ cell specification
8. Germ line cycle in mouse
9. Mechanism of PGC specification in mice
10. Specification and demarcation of PGCs
11. Genetic basis of germ cell specification in mice
12. Single cell cDNAs and somatic neighbours
13. Genes involved in PGC specification
14. fragilis/stella expression during PGC specification
15. Mechanism of PGC specification in mice
16. Mechanism of somatic programme repression
17. HMTases in single PGCs and somatic neighbours
18. Blimp1: transcrip. regulator/cell fate determinator
19. Blimp1: regulator of PGC specification in mice
20. Blimp1: expression starts earlier than stella
21. Blimp1: expressed early during development
22. Blimp1: no. of positive cells during development
23. Blimp1: positive cells are lineage restricted PGCs
24. Evidence for role of Blimp1 in PGC specification
25. Blimp1: analysis in PGC specification
26. Loss of Blimp1 causes loss of founder PGCs
27. Aberrant phenotype of Blimp1 deficient cells
28. Analysis of single PGCs and somatic neighbours
29. Summary: key points in PGC specification in mice
30. Potential mechanisms of repression by Blimp-1
31. Epigenetic programming in gonadal PGCs
32. Epigenetic modifications after PGC specification
33. Nanog expression in Stella positive nascent PGCs
34. stella/nanog/Gdf3 are linked in mouse and human
35. Key histone modifications after PGC specification
36. Germ line reprogramming
37. Genetic programme for specification of PGC fate
38. PGCs and pluripotent SCs: reversible phenotypes
39. Epigenetic programming in embryos and PGCs
40. Conclusions
41. Acknowledgements

Topics Covered

• The germ cell cycle and the key epigenetic programming events in the germ cell lineage
• the oocyte and its properties
• epigenetic mechanism of germ cell specification in mice
• repression of the somatic programme, a key event during specification of germ cells
• epigenetic programming following specification of germ cells
• the relationship between germ cells and pluripotent stem cells

Links

Series:

• Epigenetics

Categories:

• Biochemistry
• Cell Biology
• Genetics & Epigenetics
• Reproduction & Development

Therapeutic Areas:

• Gynaecology & Obstetrics

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. Azim Surani has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.