• Epidemiology
• 37 min
  1. Assessment of obesity and classification of patients: historical perspectives and current practice

  • Prof. George Bray
• 40 min
  2. Epidemiology of obesity

  • Prof. Jacob Seidell
• Etiology and Causes
• 59 min
  3. Metabolic, adipose tissue and muscle predictors of obesity

  • Prof. Ian Macdonald
• 41 min
  4. Neural control of food intake and energy balance

  • Prof. Hans-Rudolf Berthoud
• 64 min
  5. Understanding obesity: genes and environment in the determination of body weight

  • Prof. Rudy Leibel
• 47 min
  6. Dietary determinants of obesity

  • Prof. Arne Astrup
• 42 min
  7. Physical inactivity as a determinant of obesity

  • Prof. Wim Saris
• 42 min
  8. Environmental causes of obesity: sociocultural, built environment and economic factors

  • Prof. Shiriki Kumanyika
• 29 min
  9. The developmental origins of obesity

  • Prof. David Barker
• Consequences of Obesity
• 46 min
  10. Obesity, dyslipoproteinemia and inflammation

  • Prof. Robert Eckel
• 23 min
  11. Pathophysiology and management of obesity related hypertension

  • Prof. Arya Sharma
• 22 min
  12. Disorders of overeating

  • Prof. Albert Stunkard
• 20 min
  13. Obesity, weight loss and health-related quality of life

  • Prof. Aila Rissanen
  • Dr. Jarmo Kaukua
• Treatment Options
• 44 min
  14. Lifestyle modification for weight control

  • Prof. Thomas Wadden
• 34 min
  15. Bariatric / obesity surgery

  • Prof. Henry Buchwald
• 48 min
  16. Can obesity be prevented in the current obesogenic environment?

  • Prof. Boyd Swinburn
• 28 min
  17. Pharmacotherapy for obesity: why it is needed

  • Prof. Joe Proietto
• 35 min
  18. Pharmacotherapy for obesity: hunger suppressors

  • Prof. Joe Proietto
• Latest Developments in the Field
• 60 min
  19. Body composition

  • Dr. Steven Heymsfield
• 56 min
  20. Adipose tissue metabolism and obesity

  • Dr. Max Lafontan
• 25 min
  21. Obesity, present and future therapies

  • Prof. Sir Stephen Bloom
• 42 min
  22. Energy expenditure in the lean and obese

  • Prof. Dale Schoeller
• 33 min
  23. Obesity and adiponectin

  • Prof. Philipp Scherer
• 44 min
  24. Ectopic fat: causes, consequences and treatment

  • Prof. Steven Smith
• 47 min
  25. Adipose-immune interactions in obesity

  • Dr. Vishwa Dixit
• 39 min
  26. Health benefits of intentional weight loss

  • Prof. Xavier Pi-Sunyer
• 39 min
  27. Childhood obesity: implications for current and future health

  • Prof. Peter T. Katzmarzyk
• 46 min
  28. The clinical assessment and management of child and adolescent obesity

  • Prof. Louise Baur
• Archived Lectures - These lectures may not cover the latest advances in the field
• 41 min
  29. Gastrointestinal peptides and food intake regulation

  • Prof. Sir Stephen Bloom
• 48 min
  30. Obesity and mortality: questions and controversy

  • Prof. David Allison
• 37 min
  31. Obesity, diabetes and the cluster of the metabolic syndrome

  • Prof. Peter Wilson
• 44 min
  32. New standards in weight management: recent and future drugs for the treatment of obesity

  • Prof. Luc Van Gaal
• 46 min
  33. Health economics of obesity: new insights

  • Dr. Anne Wolf
• 34 min
  34. Bariatric surgery: techniques and mechanisms of action

  • Prof. Walter Pories
• 39 min
  35. Childhood obesity: implications for future health

  • Prof. Peter T. Katzmarzyk
• 14 min
  36. Pharmacotherapy for obesity 1 - the need for pharmacotherapy in weight management

  • Prof. Joe Proietto
• 46 min
  37. Pharmacotherapy for obesity 2 - pharmacological agents in current use & under development

  • Prof. Joe Proietto

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Global prevalance of obesity
3. Current and coming anti-obesity agents
4. Bariatric surgery - the only successful therapy
5. Skin redundancy after massive weight loss
6. The gut hormones
7. Ghrelin
8. Energy intake after administration of ghrelin
9. Meal intake after ghrelin infusion in cancer patients
10. Why do you feel less hungry after a meal?
11. Gut hormones: three types of satiety action
12. Peptide YY (PYY) (1)
13. GI tract distribution of PYY
14. Post prandial secretion of PYY
15. Peptide YY (PYY) (2)
16. PYY levels in different patients
17. PYY levels elevated post bypass surgery
18. Effect of PYY3-36 on food intake (1)
19. Effect of PYY3-36 on food intake (2)
20. Effect of PYY3-36 on cumulative 24h food intake
21. PYY3-36 hunger scores
22. PYY3-36 on ghrelin
23. PYY levels during saline infusion
24. Meal calories and PYY blood level in fat and thin
25. Plasma PYY levels at each infusion dose
26. Percent reduction in calories after PYY infusion
27. Food intake increased after PYY
28. Three characteristics of PYY3-36 on appetite
29. Glucagon-like peptide 1
30. The effect of chronic GLP-1 on body weight
31. Exendin stimulates food intake in satiated rats
32. 24 week trial of exenatide against insulin glargine
33. 82 weeks follow up
34. Oxyntomodulin (1)
35. Oxyntomodulin (2)
36. Chronic IP administration of oxyntomodulin
37. Effect of oxyntomodulin on food intake in humans
38. Four week oxyntomodulin trial
39. Trial protocol
40. Type of administration
41. Oxyntomodulin effect on weight loss
42. Oxyntomodulin effect on leptin levels
43. Oxyntomodulin effect on calorie intake
44. Oxyntomodulin effect on insulin levels
45. Effect on energy expenditure
46. Oxyntomodulin and energy balance
47. Design of oxyntomodulin analogues
48. Oxyntomodulin analogue 23/36
49. Effect of oxyntomodulin analogue on weight loss
50. Oxyntomodulin versus GLP-1
51. Manganese enhanced MRI
52. Ghrelin manganese enhanced MRI
53. GLP1 against oxyntomodulin
54. Buffet meal energy intake
55. Human pancreatic polypeptide (1)
56. Human pancreatic polypeptide (2)
57. Effect of hPP analogues on food intake
58. Effect of PYY, hPP or combination on food intake
59. Peptides as drugs - better targeted
60. Rimonabant and oxyntomodulin are additive
61. Concluding remarks

Topics Covered

• Anti-obesity agents
• Bariatric surgery
• The gut hormones
• Ghrelin
• Energy intake free-choice meal
• Meal intake after Ghrelin infusion
• Why do you feel less hungry after a meal?
• Three types of satiety action
• Peptide YY (PYY)
• GI tract distribution of PYY
• Post-prandial secretion of PYY
• Effect of PYY on food intake
• Glucagon-like peptide 1
• The effect of chronic GLP-1 on body weight
• Oxyntomodulin
• Leptin change
• Human pancreatic polypeptide
• Peptides as drugs: better targeted

Links

Series:

• Obesity

Categories:

• Clinical Practice
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on March 31, 2009
• Archived on November 30, 2015

Financial Disclosures

• Prof. Sir Stephen Bloom, Grant/Research Support (Principal Investigator): Medical Research Council