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1. Introduction
2. Sir William Osler
3. Variability in human pain sensitivity - experimental
4. Is variability in human pain sensitivity real?
5. Variability in human pain sensitivity - clinical
6. Variability in clinical morphine analgesia
7. Nature and nurture
8. Heritability of pain-related traits
9. Study of 49degrees C tail-withdrawal latency variability
10. Classification and regression tree (CART) results
11. G, E and GxE in the tail-withdrawal test
12. "Pain genes"
13. The pain genes database
14. Genes responsible for monogenic pain disorders
15. Finding pain variability genes - two choices
16. Genes potentially associated with pain states
17. The problem with association studies
18. Finding pain variability genes - other choices
19. Fancy mice: origin of inbred strains
20. Twelve inbred mouse strains
21. Inbred mice responses to nociceptive assays
22. Correlations among pain tests in inbred mice
23. Genetic "clusters" of pain tests
24. Qualitative strain differences in pain
25. Differences in pain tests and pain processing
26. Statistically confirmed pain-relevant QTLs
27. MC1Rs and pain - mice and humans
28. Candidate genes and positional cloning
29. The formalin test
30. Responses of inbred mice to 5% formalin
31. Two formalin test QTLs: Nociq1and Nociq2
32. Haplotype mapping
33. Haplotype mapping of chrom. 9 formalin test QTL
34. Atp1b3
35. Atp1b3 differential expression in two mice strains
36. siRNA knockdown of Atp1b3
37. Take-away messages
38. Acknowledgments

Topics Covered

• Variability in pain sensitivity and analgesia
• Heritability of pain
• Genetic and environmental contributions to pain
• Pain genes
• Monogenic pain disorders
• Association studies
• Inbred mouse strains and strain differences
• Genetic correlations among pain phenotypes
• Quantitative trait loci (QTLs)
• Melanocortin-1 receptors and pain
• Formalin test QTLs
• Haplotype mapping
• Atp1b3 and formalin pain

Links

Series:

• Pain and the Control of Pain

Categories:

• Clinical Practice
• Genetics & Epigenetics
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on January 26, 2009

Financial Disclosures

• Prof. Jeffrey S. Mogil has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.