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1. Introduction
2. Lecture topics
3. Visceral pain vs. cutaneous pain
4. Assessing sensation from the viscera
5. Psychophysical function shifted leftward in IBS
6. Input from GI-tract and bladder to the spinal cord
7. Characteristics of visceral nociceptors
8. Both mechanoreceptors encode in noxious range
9. Visceral nociceptors sensitization
10. Visceral silent ("sleeping") nociceptors
11. Consequences of visceral insult
12. Molecular targets
13. Colon mechanosensitivity in knockout mice
14. In vitro afferent fiber recording
15. Classes of mechanosensitive afferents
16. Differences between colonic LuSN and PN
17. Sensitivity to colon stretch in TRPV1, ASIC3 k.o.
18. Chemical exposure sensitizes strech response
19. Sensitization is partially blocked in TRPV1 k.o.
20. Sensitization is absent in ASIC3 k.o.
21. Consequences of visceral insult
22. Central sensitization in IBS patients
23. Colon inflammation produces hypersensitivity
24. Colon inflammation and sP receptor internalization
25. Central contributions to visceral hypersensitivity
26. Colon inflammation produces supraspinal changes
27. CNS modulation of visceral pain
28. Summary
29. Acknowledgements

Topics Covered

• Visceral Pain
• Diffuse, referred and typically difficult to manage
• Visceral Hypersensitivity
• Defining characteristic of functional gastrointestinal disorders
• Contributed to by both peripheral and central mechanisms

Links

Series:

• Pain and the Control of Pain

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on January 26, 2009

Financial Disclosures

• Prof. Gerald Gebhart has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.