• The Nociceptor
• 43 min
  1. Primary afferent nociceptors

  • Prof. Hermann Handwerker
• 40 min
  2. Sodium channels and pain

  • Prof. Stephen Waxman
• Central Nervous System Mechanisms of Pain Generation
• 46 min
  3. Pain mechanisms in the spinal cord

  • Prof. Fernando Cervero
• 48 min
  4. Central sensitization

  • Prof. Clifford Woolf
• 41 min
  5. Thalamo-cortical pain mechanisms

  • Prof. Frederick Lenz
• Pain Modulation: Mechanisms
• 36 min
  6. Opioid receptor pharmacology and pain

  • Prof. Margarita Puig
• 36 min
  7. The descending modulation of pain

  • Dr. Kirsty Bannister
• 48 min
  8. Spinal drug delivery: technology, biology and toxicology

  • Prof. Tony Yaksh
• 22 min
  9. Forebrain mechanisms of pain modulation

  • Prof. M. Catherine Bushnell
• Major Pain Conditions: Presentations and Mechanisms
• 52 min
  10. Visceral pain and visceral hypersensitivity

  • Prof. Gerald Gebhart
• 46 min
  11. Neuropathic pain: presentation, mechanisms and management

  • Dr. Chris Wells
• 37 min
  12. Cortical spreading depression and translational mechanisms in migraine headache

  • Prof. Michael Moskowitz
• Pain Management: Clinical Approaches
• 71 min
  13. Clinical pharmacology of pain

  • Prof. Eija Kalso
• 63 min
  14. Psychological approaches to pain

  • Prof. Jennifer Haythornthwaite
• Other Pain Topics
• 47 min
  15. Pain in children

  • Prof. Patricia McGrath
• 35 min
  16. Pain processing in early life

  • Prof. Maria Fitzgerald
• 37 min
  17. The genetics of pain

  • Prof. Jeffrey S. Mogil
• 57 min
  18. Congenital syndromes of pain and painlessness

  • Prof. Geoff Woods
  • Prof. James Cox
• Archived Lectures *These may not cover the latest advances in the field
• 43 min
  19. Descending control systems

  • Prof. Ronald Dubner
• 40 min
  20. Functional pain disorders

  • Prof. Emeran Mayer

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Opioid receptors: relevance
3. Opioids in pain management
4. Opioid analgesics: pharmacology
5. The endogenous opioid system
6. Modulation of nociceptive transmission
7. Endogenous opioid peptides: targets for analgesia
8. Opioid receptors: general structure
9. Characteristics of opioid receptors
10. Opioid receptors: effector systems
11. Opioid receptor activation
12. Opioid-receptor-mediated effects
13. Opioid receptors: clinically relevant characteristics
14. Mu opioid receptor polymorphisms
15. Opioid receptor dimerization
16. Opioid receptor internalization
17. Endogenous opioids and opioid receptors location
18. Opioid receptors at peripheral sites
19. Opioids: local (peripheral) analgesia (1)
20. Opioids: local (peripheral) analgesia (2)
21. How to obtain an opioid analgesia
22. Opioid analgesia: gene therapy with viral vectors
23. Cell transfection with a viral vector
24. Advantages and problems of viral vectors therapy
25. A viral vector expressing the pro-enkephalin gene
26. Drugs that activate opioid receptors
27. Characteristics of opioid analgesics
28. Opioids: classification
29. Opioid analgesics: sites and mechanism
30. Opioid analgesics: pharmacological effects
31. Opioid administration
32. Opioid-induced paradoxical pain vs. tolerance
33. Opioid-induced hyperalgesia: paradoxical pain
34. Opioid analgesia and hyperalgesia
35. Hyperalgesia after acute administration: animals
36. Hyperalgesia after acute administration: humans
37. Tolerance: IASP definition
38. Tolerance after exposure to opioids
39. Opioid tolerance: clinical issues
40. Opioid administration: tolerance
41. Peripheral opioid antagonists
42. Peripheral opioid antagonists: rationale
43. Peripheral opioid antagonists: examples
44. Tolerance: prevention / reversal
45. Clinical use: analgesic drug combinations
46. Clinical use: multimodal or balanced analgesia
47. Opioids in pain management: summary
48. Principle for safe and effective opioid use
49. Thank you

Topics Covered

• Opioid receptors: relevance
• Opioids in pain management
• Opioid analgesics: pharmacology
• The endogenous opioid system
• Endogenous opioid peptides
• Effector systems
• Opioid receptor activation
• Opioid receptor mediated effects
• Opioid receptor polymorphisms
• Dimerization
• Internalization
• Endogenous opioids and opioid receptors are located at peripheral, spinal and supraspinal sites
• Opioid analgesia
• Cell transfection with a viral vector
• Viral vectors expressing endogenous opioid precursors
• Drugs that activate opioid receptors
• Opioid administration
• Paradoxical pain and tolerance
• Opioid-induced hyperalgesia: paradoxical pain
• Tolerance
• Peripheral opioid antagonists
• Clinical use of opioids
• Opioids in pain management
• Principle for safe and effective opioid use

Links

Series:

• Pain and the Control of Pain

Categories:

• Clinical Practice
• Neuroscience
• Pharmaceutical Sciences

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on January 26, 2009

Financial Disclosures

• Prof. Margarita Puig has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.