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1. Introduction
2. Descartes
3. Linear pain pathway
4. Real pain
5. Dorsal horn crossroads
6. Gate control theory
7. The role of the spinal cord in pain transmission
8. List of topics
9. Anatomical data on primary afferent nociceptors
10. Types of primary sensory afferents
11. Rexed's laminae
12. Dorsal horn morphology
13. Viscero-somatic convergence
14. Histology of the dorsal horn of the spinal cord
15. Sensory outputs of the spinal cord
16. Conclusions (1)
17. Response to visceral and peripheral inputs
18. Wide dynamic range neurons (WDR)
19. Nociceptor-specific neurons (NS)
20. Differences between WDR and NS neurons
21. Functional roles WDR and NS neurons
22. Conclusions (2)
23. Primary sensory neurons and 2nd order neurons
24. The dynamics of pain sensation
25. Irritable focus
26. Mechanisms of hyperalgesia
27. Wind-up of a nociceptive dorsal horn neuron
28. Receptive field expansion
29. Receptive field sensitization
30. Conclusions (3)
31. Descending modulation of pain transmission
32. Inhibitory and excitatory control of transmission
33. General conclusions
34. Acknowledgments

Topics Covered

• Role of the spinal cord in pain processing
• The dorsal horn of the spinal cord as a crossroads for pain transmission
• Projection of primary sensory afferents to the spinal dorsal horn
• Sensory outputs of the spinal cord
• Classes of spinal cord neuron involved in pain processing
• Role of the spinal cord in hyperalgesic states
• Sensitization of spinal cord neurons
• Descending modulation of pain transmission through the spinal cord

Links

Series:

• Pain and the Control of Pain

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on January 26, 2009
• Archived on May 28, 2025

Financial Disclosures

• Prof. Fernando Cervero has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.