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- Introduction to Cancer Therapy
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1. Early detection of lung cancer
- Prof. Stephen Lam
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2. Development of a cancer drug
- Prof. Martin Edelman
- Use of Novel "Targeted" Agents in Combination with Classical Cytotoxic Chemotherapy
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3. Cytotoxic chemotherapy
- Dr. Michael Sawyer
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4. Small molecule inhibitors of receptor tyrosine kinases
- Dr. Daniela Krause
- Innovative Strategies of Clinical Drug Development
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5. Phase II trials
- Dr. Patricia Tang
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6. Surrogate endpoints of efficacy
- Prof. Maurie Markman
- Biomarkers in Oncology: Rationale Development and Current Use
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7. Biomarkers in oncology: overview
- Prof. Joe Duffy
- Archived Lectures *These may not cover the latest advances in the field
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9. Emerging trends in phase II trial design
- Dr. Patricia Tang
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11. Therapy in cancer 2008: quo vadis?
- Dr. Jeffrey Clark
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13. Phase III trials
- Prof. Martin Edelman
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15. Gene profiling in breast cancer
- Dr. Enrique Espinosa
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18. Understanding cancer trends
- Prof. Michael Thun
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20. Phase I study design for non-cytotoxic agents
- Dr. Wendy Parulekar
Printable Handouts
Navigable Slide Index
- Introduction
- Irinotecan (CPT-11, camptosar)
- Treatment of metastatic CRC
- Safety of irinotecan (1)
- Safety of irinotecan (2)
- Illustration of metabolic pathway of irinotecan
- Glucuronidation of SN-38 vs. toxicity
- Schematic illustration of UGT1A
- Candidate polymorphism: UGT1A1*28, (TA)7
- UGT1A1*28 genotype-phenotype association (1)
- UGT1A1*28 genotype-phenotype association (2)
- Revised irinotecan package insert (Mar 2005)
- Invader: UGT1A1molecular assay (Aug 2005)
- Role of UGT1A1*28 in metastatic CRC
- Unanswered questions
- UGT1A1*28 frequency in 3 different ethnic groups
- Another candidate polymorphism: UGT1A1*7
- Frequency of UGT1A1*6 in Asians
- UGT1A1*6 genotype-phenotype association
- Efficacy in UGT1A1*28-genotyped patients
- Irinotecan dose and hematologic toxicity
- Individualization of chemotherapy
- Genotype-based dosing of irinotecan (1)
- Genotype-based dosing of irinotecan (2)
- Role of other UGT1A
- Metabolic pathway of irinotecan: transporters
- Limitation of previous studies
- Conclusions
Topics Covered
- Irinotecan activity and safety
- Metabolism of Irinotecan
- Structure of UGT1A
- Role of UGT1A1*28 on irinotecan pharmacogenetics
- Role of UGT1A1*6 in Asians
- Genotype-based dosing of irinotecan
- Other candidates: UGT1A enzyme or transporter
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Kim, T.W. (2009, January 6). UGT1A1 polymorphisms and irinotecan toxicity in colorectal cancer patients [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/1122/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Tae Won Kim has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
UGT1A1 polymorphisms and irinotecan toxicity in colorectal cancer patients
A selection of talks on Clinical Practice
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