• The Notion of Epigenetics
• 43 min
  1. Cytoplasmic epigenetics: inheritance by cytoplasmic continuity

  • Prof. Philippe Silar
  • Dr. Fabienne Malagnac
• Epigenetics: Paradigms
• 38 min
  2. The molecular mechanism of X chromosome inactivation

  • Prof. Neil Brockdorff
• 29 min
  3. Genomic imprinting: history and embryology

  • Prof. Davor Solter
• 48 min
  4. X chromosome inactivation in human cells

  • Prof. Barbara Migeon
• 41 min
  5. RNAi and heterochromatin in plants and fission yeast

  • Prof. Robert Martienssen
• Epigenetics: Mechanisms
• 23 min
  6. Polycomb epigenetic mechanisms: role of PcG complexes

  • Prof. Vincenzo Pirrotta
• 29 min
  7. Polycomb epigenetic mechanisms: methylation of DNA

  • Prof. Vincenzo Pirrotta
• 56 min
  8. Histone modifications and prospects for an epigenetic code

  • Prof. Bryan Turner
• 68 min
  9. Epigenetic control by histone methylation

  • Prof. Thomas Jenuwein
• 38 min
  10. Histone dynamics, heritability and variants

  • Dr. Genevieve Almouzni
• 51 min
  11. Gene silencing in budding yeast

  • Prof. Susan Gasser
• Epigenetics: Heritability and Reversibility
• 51 min
  12. Nuclear cloning, stem cells and epigenetic reprogramming

  • Prof. Rudolf Jaenisch
• 64 min
  13. Stem cell memory

  • Prof. James Sherley
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  14. Epigenetics: a historical overview

  • Dr. Robin Holliday
• 43 min
  15. DNA methylation

  • Prof. Adrian Bird
• 45 min
  16. DNA methylation and genome defense in Neurospora crassa

  • Prof. Eric Selker
• 34 min
  17. A historical perspective on ideas on X-chromosome inactivation

  • Dr. Mary Lyon
• 40 min
  18. Evolution of mammal epigenetic control systems

  • Prof. Jenny Graves
• 60 min
  19. Genomic imprinting and its regulation

  • Dr. Anne Ferguson-Smith
• 40 min
  20. Nuclear organization and gene expression

  • Prof. David Spector
• 39 min
  21. Germ cells

  • Prof. Azim Surani
• 41 min
  22. Epigenetic regulation of phenotype

  • Prof. Emma Whitelaw
• 68 min
  23. Epigenetically mediated gene silencing: a companion to genetic alterations in driving tumorigenesis

  • Prof. Stephen Baylin
• 36 min
  24. Cytoplasmic epigenetics: proteins acting as genes

  • Prof. Reed Wickner

Printable Handouts

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Navigable Slide Index

1. X-Chr. inactivation (XCI): historical perspective
2. XCI: thoughts
3. Preludes to discovery of XCI
4. Dosage compensation mechanism
5. Extension of theory to human-X
6. Genes escaping XCI
7. XCI applies only to somatic cells
8. Properties of inactive-X
9. Mouse X-autosome translocations
10. Function of inactivation centre
11. Gene variegation percentage and inactivation
12. Developments in the theory of XCI
13. Some causes of skewing of XCI
14. Some cases of apparent non-random inactivation
15. Non-random inactivation: coat color in mouse
16. Suggested XCI mechanism
17. Properties of inactive-X
18. X-chromosome imprinting
19. Imprinted/random inactivation
20. XX embryonic stem cells
21. XIST gene
22. knockouts of Xist in XX cells
23. knockouts of Xist in XY cells
24. XIST/Xist sequence
25. Xsit antisense transcript Tisx
26. Differences between human and mouse
27. Effect of Xist YAC on autosome Chr. 12
28. Xist cDNA transgene in ES cells
29. Properties of inactive-X
30. Cycle of X chromosome activity in development
31. X-chromosomal DNA facilitates XCI
32. LINE1s on human-X
33. Recent work on X;A translocations
34. X-reactivation in mouse

Topics Covered

• The phenomenon of X-chromosome inactivation in female mammals
• X-chromosome inactivation as a dosage compensation mechanism for equalising the dosage of X-linked gene products in XY males and XX females in somatic cells
• inactivity of either the maternal or paternal X-chromosome in different cells in eutherian mammals
• preferential inactivation of paternal X in the placenta of mice and in all cells of marsupials
• initiation of the process from an X-inactivation centre
• discovery of the key gene, Xist
• the concept of initiation and maintenance of X-inactivation as separate processes
• histone modifications and methylation of CpG islands as maintenance mechanisms
• inactivation in autosomal and X-chromosomal DNA
• LINE1s as booster elements on the X-chromosome

Links

Series:

• Epigenetics

Categories:

• Biochemistry
• Cell Biology
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 31, 2016

Financial Disclosures

• Dr. Mary Lyon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.