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- Epidemiology and Risk Factors
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1. Coronary heart disease epidemiology: global context for a new genetic understanding
- Prof. Harry Hemingway
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2. Cardiovascular risk factors
- Dr. Michal Vrablik
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3. Lipoproteins
- Prof. Arnold von Eckardstein
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4. Thrombotic risk factors for cardiovascular disease
- Prof. Gordon Lowe
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5. Lipoprotein(a)
- Dr. Jaimini Cegla
- Biology of Coronary Heart Disease
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6. Plaque rupture
- Prof. Petri Kovanen
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7. Transcription factors and complex disease development
- Dr. Ines Pineda-Torra
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8. Animal models to explore cardiovascular disease
- Prof. Martin Merkel
- Treatment
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9. Diagnosis and treatment of dyslipidemias
- Prof. Anton Stalenhoef
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10. Key drug discovery challenges in cardiovascular medicine
- Dr. Dan Swerdlow
- Dr. Michael V. Holmes
- Genetics
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11. Moving from GWAS hits to functional variants
- Prof. Steve Humphries
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12. Heart disease genes and SNPs
- Prof. Steve Humphries
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13. Familial hypercholesterolaemia: genetic causes and treatment
- Prof. Steve Humphries
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14. Familial hypercholesterolaemia: cascade testing and monogenic vs. polygenic causes
- Prof. Steve Humphries
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16. Genetics of cardiovascular disease
- Prof. Philippa Talmud
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17. The genetics of CHD: moving research findings into patient benefit
- Prof. Steve Humphries
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19. The genetics of abdominal aortic aneurysm
- Dr. Seamus Harrison
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20. Genome scans for hypertension
- Prof. Patricia Munroe
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21. Telomeres and cardiovascular disease
- Dr. Jess Buxton
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23. Genetics of hypertrophic cardiomyopathy (HCM)
- Dr. Petros Syrris
- Archived Lectures *These may not cover the latest advances in the field
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24. Gene-environment interaction and oxidative stress in cardiovascular disease
- Dr. Jeffrey Stephens
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25. Gene therapy as a therapeutic option for lipoprotein lipase deficiency
- Dr. Jan Albert Kuivenhoven
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26. Cardiovascular diseases: from epidemiology to nutritional interventions
- Dr. Antonis Zampelas
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27. Genetic testing for CHD risk: fact or fiction?
- Prof. Steve Humphries
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28. Pharmacogenetics: progress, pitfalls and clinical potential
- Prof. Steve Humphries
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29. Familial hyperchlolesterolaemia: a monogenic cause of early CHD
- Prof. Steve Humphries
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30. Lipid metabolism
- Dr. Ulrike Beisiegel
Printable Handouts
Navigable Slide Index
- Introduction
- The ideal animal model for cardiovascular disease
- Exploring CVD in animals
- Nonhuman primates
- Pigs
- Rabbits
- Example: Watanabe rabbit
- Rats
- Rats in atherosclerosis research
- Mice our friends in science
- Why mice?
- Do mice get atherosclerosis?
- Lipid profile in humans and mice
- Mouse lipid metabolism
- Mice are not man!
- Laboratory mice: where do they come from?
- Inbred mouse strains
- Generating an inbred mouse line
- Genealogical trees of coomon mice lines
- Inbred mouse strains: terms and importance
- Genetic modifications of mice
- Transgenic technique (1)
- Transgenic technique (2)
- Transgenic mice: properties
- Transgenic mouse lines: example (1)
- Transgenic mouse lines: example (2)
- Homologous recombination: overview
- Homologous recombination (1)
- Homologous recombination (2)
- Homologous recombination: use
- Common atherosclerosis and obesity mice models
- ApoE deficient mice
- Aortic root atherosclerosis in apoE deficient mice
- ApoE deficient mice: draw backs
- LDL receptor deficient mice
- LDL receptor deficient mice: atherosclerosis
- apoB100 transgenic mice
- apoE3 Leiden transgenic mice
- Other mouse lines for atherosclerosis and obesity
- Summary and recommendations
- Selected reading
Topics Covered
- Atherosclerosis is a complex disease involving several different molecular and cellular mechanisms in its pathogenesis
- For its experimental investigation, usually higher animals as mammals need to be employed
- Here, the animal models currently used in atherosclerotic research are reviewed und their respective advantages and disadvantages are depicted
- Use of inbred mouse strains and different genetically modified mice
- The main disparities between mouse and human lipid metabolism
- Considerations and techniques to create useful animal models
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Merkel, M. (2008, November 24). Animal models to explore cardiovascular disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 21, 2025, from https://doi.org/10.69645/YLWJ7869.Export Citation (RIS)
Publication History
- Published on November 24, 2008
Financial Disclosures
- Prof. Martin Merkel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.