• Epidemiology and Risk Factors
• 23 min
  1. Coronary heart disease epidemiology: global context for a new genetic understanding

  • Prof. Harry Hemingway
• 44 min
  2. Cardiovascular risk factors

  • Dr. Michal Vrablik
• 29 min
  3. Lipid metabolism

  • Dr. Ulrike Beisiegel
• 39 min
  4. Thrombotic risk factors for cardiovascular disease

  • Prof. Gordon Lowe
• Biology of Coronary Heart Disease
• 42 min
  5. Plaque rupture

  • Prof. Petri Kovanen
• 56 min
  6. Transcription factors and complex disease development

  • Dr. Ines Pineda-Torra
• 39 min
  7. Animal models to explore cardiovascular disease

  • Prof. Martin Merkel
• Treatment
• 26 min
  8. Diagnosis and treatment of dyslipidemias

  • Prof. Anton Stalenhoef
• 31 min
  9. Key drug discovery challenges in cardiovascular medicine

  • Dr. Dan Swerdlow
  • Dr. Michael V. Holmes
• Genetics
• 50 min
  10. Moving from GWAS hits to functional variants

  • Prof. Steve Humphries
• 51 min
  11. Heart disease genes and SNPs

  • Prof. Steve Humphries
• 39 min
  12. Familial hypercholesterolaemia: genetic causes and treatment

  • Prof. Steve Humphries
• 22 min
  13. Familial hypercholesterolaemia: cascade testing and monogenic vs. polygenic causes

  • Prof. Steve Humphries
• 28 min
  14. Familial hypercholesterolaemia: case studies, universal screening and novel mutations

  • Prof. Steve Humphries
• 52 min
  15. Genetics of cardiovascular disease

  • Prof. Philippa Talmud
• 35 min
  16. Mendelian randomisation: using genetics to determine causality

  • Dr. Tina Shah
• 33 min
  17. The genetics of abdominal aortic aneurysm

  • Dr. Seamus Harrison
• 49 min
  18. Genome scans for hypertension

  • Prof. Patricia Munroe
• 43 min
  19. Telomeres and cardiovascular disease

  • Dr. Jess Buxton
• 33 min
  20. Translational applications of cardiovascular genomics: opportunities and challenges

  • Dr. Aroon Hingorani
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  21. Gene-environment interaction and oxidative stress in cardiovascular disease

  • Dr. Jeffrey Stephens
• 34 min
  22. Gene therapy as a therapeutic option for lipoprotein lipase deficiency

  • Dr. Jan Albert Kuivenhoven
• 60 min
  23. Cardiovascular diseases: from epidemiology to nutritional interventions

  • Dr. Antonis Zampelas
• 45 min
  24. Genetic testing for CHD risk: fact or fiction?

  • Prof. Steve Humphries
• 35 min
  25. Pharmacogenetics: progress, pitfalls and clinical potential

  • Prof. Steve Humphries
• 50 min
  26. Familial hyperchlolesterolaemia: a monogenic cause of early CHD

  • Prof. Steve Humphries

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The ideal animal model for cardiovascular disease
3. Exploring CVD in animals
4. Nonhuman primates
5. Pigs
6. Rabbits
7. Example: Watanabe rabbit
8. Rats
9. Rats in atherosclerosis research
10. Mice our friends in science
11. Why mice?
12. Do mice get atherosclerosis?
13. Lipid profile in humans and mice
14. Mouse lipid metabolism
15. Mice are not man!
16. Laboratory mice: where do they come from?
17. Inbred mouse strains
18. Generating an inbred mouse line
19. Genealogical trees of coomon mice lines
20. Inbred mouse strains: terms and importance
21. Genetic modifications of mice
22. Transgenic technique (1)
23. Transgenic technique (2)
24. Transgenic mice: properties
25. Transgenic mouse lines: example (1)
26. Transgenic mouse lines: example (2)
27. Homologous recombination: overview
28. Homologous recombination (1)
29. Homologous recombination (2)
30. Homologous recombination: use
31. Common atherosclerosis and obesity mice models
32. ApoE deficient mice
33. Aortic root atherosclerosis in apoE deficient mice
34. ApoE deficient mice: draw backs
35. LDL receptor deficient mice
36. LDL receptor deficient mice: atherosclerosis
37. apoB100 transgenic mice
38. apoE3 Leiden transgenic mice
39. Other mouse lines for atherosclerosis and obesity
40. Summary and recommendations
41. Selected reading

Topics Covered

• Atherosclerosis is a complex disease involving several different molecular and cellular mechanisms in its pathogenesis
• For its experimental investigation, usually higher animals as mammals need to be employed
• Here, the animal models currently used in atherosclerotic research are reviewed und their respective advantages and disadvantages are depicted
• Use of inbred mouse strains and different genetically modified mice
• The main disparities between mouse and human lipid metabolism
• Considerations and techniques to create useful animal models

Links

Series:

• Genetics of Cardiovascular Disease

Categories:

• Clinical Practice

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on November 24, 2008

Financial Disclosures

• Prof. Martin Merkel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.