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Printable Handouts
Navigable Slide Index
- Introduction
- The ideal animal model for cardiovascular disease
- Exploring CVD in animals
- Nonhuman primates
- Pigs
- Rabbits
- Example: Watanabe rabbit
- Rats
- Rats in atherosclerosis research
- Mice our friends in science
- Why mice?
- Do mice get atherosclerosis?
- Lipid profile in humans and mice
- Mouse lipid metabolism
- Mice are not man!
- Laboratory mice: where do they come from?
- Inbred mouse strains
- Generating an inbred mouse line
- Genealogical trees of coomon mice lines
- Inbred mouse strains: terms and importance
- Genetic modifications of mice
- Transgenic technique (1)
- Transgenic technique (2)
- Transgenic mice: properties
- Transgenic mouse lines: example (1)
- Transgenic mouse lines: example (2)
- Homologous recombination: overview
- Homologous recombination (1)
- Homologous recombination (2)
- Homologous recombination: use
- Common atherosclerosis and obesity mice models
- ApoE deficient mice
- Aortic root atherosclerosis in apoE deficient mice
- ApoE deficient mice: draw backs
- LDL receptor deficient mice
- LDL receptor deficient mice: atherosclerosis
- apoB100 transgenic mice
- apoE3 Leiden transgenic mice
- Other mouse lines for atherosclerosis and obesity
- Summary and recommendations
- Selected reading
Topics Covered
- Atherosclerosis is a complex disease involving several different molecular and cellular mechanisms in its pathogenesis
- For its experimental investigation, usually higher animals as mammals need to be employed
- Here, the animal models currently used in atherosclerotic research are reviewed und their respective advantages and disadvantages are depicted
- Use of inbred mouse strains and different genetically modified mice
- The main disparities between mouse and human lipid metabolism
- Considerations and techniques to create useful animal models
Links
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Talk Citation
Merkel, M. (2008, November 24). Animal models to explore cardiovascular disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 6, 2024, from https://doi.org/10.69645/YLWJ7869.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Martin Merkel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.