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1. Introduction
2. Introduction (2)
3. Problems with current risk factors
4. Effects of risk factors on CVD mortality
5. Prediction of CHD in diabetes
6. Oxidative stress and cardiovascular risk
7. Molecular consequences of oxidative stress
8. The polygenic nature of CHD
9. Gene environment interaction
10. Genes load the gun, environment pulls the trigger
11. Genetic & biochemical markers of oxidative stress
12. Aim of this presentation
13. Measurement of oxidative stress
14. Plasma Total Antioxidant Status (TAOS)
15. Mitochondrial uncoupling protein 2
16. A novel antioxidant UCP2 ?
17. Mitochondria are major source of cellular ROS
18. UCL-diabetes and cardiovascular disease study
19. Northwick park heart study II
20. Prospective CHD risk by plasma TAOS in NPHSII
21. UCP2 common variants
22. Plasma TAOS and UCP2 -866G>A genotype
23. Oxidative stress and UCP2 -866G>A genotype
24. Plasma TAOS, smoking, and UCP2 -866G>A
25. UCP2 genotype and CHD risk in NPHSII
26. Other CHD risk factors
27. The important of UCP2
28. UCP2 environment interaction and CHD risk
29. Does statin treatment reduce oxidative stress?
30. Apolipoprotein E (APOE)
31. APOE and CHD risk
32. APOE genotype and CHD risk
33. APOE and oxidative stress
34. The APOE genotype interaction with smoking
35. Glutathione s-transferase gene (GST)
36. GSTs and oxidative stress
37. The role of glutathione s-transferase
38. GST gene variants
39. GST gene variants and CVD
40. Plasma Ox-LDL by GSTT1 genotype & smoking
41. Other gene variants (1)
42. Other gene variants (2)
43. Summary overview
44. Acknowledgments

Topics Covered

• Oxidative stress: a risk factor for CVD
• Biochemical markers of oxidative stress
• Genetic determinants of oxidative stress: examples
• Examples of gene-environment interaction in determining oxidative stress and CVD
• Other gene variants and oxidative stress

Links

Series:

• Genetics of Cardiovascular Disease

Categories:

• Clinical Practice
• Genetics & Epigenetics

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Stephens, J. (2008, November 24). Gene-environment interaction and oxidative stress in cardiovascular disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/QYWF3240.
Export Citation (RIS)

Publication History

• Published on November 24, 2008
• Archived on February 25, 2021

Financial Disclosures

• Dr. Jeffrey Stephens has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.