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1. Introduction
2. Definition of 'epigenetics'
3. Non-chromosomal components of yeast genome
4. Inheritance vs. infection
5. Prions: definition and classification
6. [URE3] and [PSI] as prions
7. Genetic criteria for a prion: illustrated with [URE3]
8. Prion domain of Ure2p
9. Comparison of prion domains
10. Amyloid: a pathogenic protein form
11. Amyloid of Ure2p is the basis of the [URE3] prion
12. Ure2p filaments are present only in [URE3] cells
13. Architecture of Ure2p amyloid filaments
14. Ure2p C-terminal domain
15. Shuffling of Ure2 prion domain
16. Sequence independence of prion domain
17. In-register structure explains prion properties
18. Amyloid assembly by Ure2p
19. Ure2 from pathogenic yeasts
20. Chaperones and prions
21. Prion variants and species barrier
22. Prion strain affects species barrier
23. Infection with prions by introduction of amyloid
24. Heterokaryon incompatibility
25. [Het-s] and meiotic drive
26. Yeast prions: help or hindrance
27. Selfish RNAs, DNAs and prions
28. Major challenges for prion research
29. References (1)
30. References (2)

Topics Covered

• Prions (infectious proteins) include several self-propagating amyloids of S. cerevisiae and Podospora anserina and a self-activating enzyme of S. cerevisiae
• these non-chromosomal genetic elements are genes composed of protein, just as nucleic acids can catalyse enzymatic reactions
• the amyloid-based prions [PSI+] and [URE3] are diseases of yeast, but the [Het-s] prion of Podospora carries out a normal function for that organism, heterokaryon incompatibility

Links

Series:

• Epigenetics

Categories:

• Biochemistry
• Cell Biology
• Genetics & Epigenetics

Talk Citation

Wickner, R. (2007, October 1). Cytoplasmic epigenetics: proteins acting as genes [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 26, 2024, from https://doi.org/10.69645/PCIC8234.
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Publication History

• Published on October 1, 2007
• Archived on December 10, 2018

Financial Disclosures

• Prof. Reed Wickner has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.