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- Epidemiology and Risk Factors
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1. Coronary heart disease epidemiology: global context for a new genetic understanding
- Prof. Harry Hemingway
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2. Cardiovascular risk factors
- Dr. Michal Vrablik
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3. Lipoproteins
- Prof. Arnold von Eckardstein
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4. Thrombotic risk factors for cardiovascular disease
- Prof. Gordon Lowe
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5. Lipoprotein(a)
- Dr. Jaimini Cegla
- Biology of Coronary Heart Disease
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6. Plaque rupture
- Prof. Petri Kovanen
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7. Transcription factors and complex disease development
- Dr. Ines Pineda-Torra
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8. Animal models to explore cardiovascular disease
- Prof. Martin Merkel
- Treatment
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9. Diagnosis and treatment of dyslipidemias
- Prof. Anton Stalenhoef
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10. Key drug discovery challenges in cardiovascular medicine
- Dr. Dan Swerdlow
- Dr. Michael V. Holmes
- Genetics
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11. Moving from GWAS hits to functional variants
- Prof. Steve Humphries
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12. Heart disease genes and SNPs
- Prof. Steve Humphries
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13. Familial hypercholesterolaemia: genetic causes and treatment
- Prof. Steve Humphries
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14. Familial hypercholesterolaemia: cascade testing and monogenic vs. polygenic causes
- Prof. Steve Humphries
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16. Genetics of cardiovascular disease
- Prof. Philippa Talmud
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17. The genetics of CHD: moving research findings into patient benefit
- Prof. Steve Humphries
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19. The genetics of abdominal aortic aneurysm
- Dr. Seamus Harrison
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20. Genome scans for hypertension
- Prof. Patricia Munroe
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21. Telomeres and cardiovascular disease
- Dr. Jess Buxton
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23. Genetics of hypertrophic cardiomyopathy (HCM)
- Dr. Petros Syrris
- Archived Lectures *These may not cover the latest advances in the field
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24. Gene-environment interaction and oxidative stress in cardiovascular disease
- Dr. Jeffrey Stephens
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25. Gene therapy as a therapeutic option for lipoprotein lipase deficiency
- Dr. Jan Albert Kuivenhoven
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26. Cardiovascular diseases: from epidemiology to nutritional interventions
- Dr. Antonis Zampelas
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27. Genetic testing for CHD risk: fact or fiction?
- Prof. Steve Humphries
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28. Pharmacogenetics: progress, pitfalls and clinical potential
- Prof. Steve Humphries
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29. Familial hyperchlolesterolaemia: a monogenic cause of early CHD
- Prof. Steve Humphries
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30. Lipid metabolism
- Dr. Ulrike Beisiegel
Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Section 1
- CVD burden increasing globally
- CVD mortality increases rapidly within generation
- The epidemiological transition
- Stages of epidemiological transition and CVD
- Global burden of disease study 2030 projections
- Where are most CHD deaths occurring?
- Diabetes and CVD death rates in EME and India
- Rate of CHD decreases in the UK
- Within/between country geographical variations
- Age as a risk factor
- CHD death rates by social class
- Interheart: MI case control study in 52 countries
- Interheat conclusions
- Obesity trends in US adults BRFSS, 1986 - 2003
- We know how to prevent CHD
- Shifting the population distribution of risk
- Summary (1)
- Section II: possible relevance of genes
- Two examples
- Sex/gender
- Deaths by cause in European women
- Male excess in coronary death in 52 countries
- What about other coronary phenotypes?
- Time trends in angina and MI
- Sex differences in angina prevalence
- Angina: no male excess across 31 countries (1)
- Angina: no male excess across 31 countries (2)
- So what?
- Finland: whole population clinical epidemiology
- Sex differences in angina incidence: Finland
- Effect of angina on CHD mortalilty
- Genome wide association studies
- Phenotypes in WTCCC GWAS
- GWAS: MI vs. CAD without MI
- Genetic influences on smoking behaviour
- Genotype and smoking quantity: Iceland
- Same effect in Spain and the Netherlands
- Genotype, lung cancer and PAD
- Study conclusions
- Summary (2)
Topics Covered
- Established importance of environment factors
- CVD burden increasing globally
- Rapid within generation increase in CVD mortality rates
- The epidemiological transition
- Stages of epidemiological transition and CVD
- Where in the world are most CHD deaths occurring?
- Within and between country geographical variations
- Age is the strongest risk factor for CVD
- CHD deaths by social class
- Interheart
- Obesity trends
- We know how to prevent CHD
- Shifting the population distribution of risk
- Possible relevance of genes
- Large scale epidemiological evidence
- Deaths by cause in women
- Coronary phenotypes
- Angina trends
- Evidence from Finland
- Genome-wide association studies
- Phenotypes in WTCCC GWAS
- Genetic influences on smoking behavior
- Genotype and smoking quantity
- Phenotypically differentiating chronic and acute syndromes of coronary disease is likely to be important
- Interplay between identified genetic variants and environmental exposures in large scale studies: watch this space
Links
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Talk Citation
Hemingway, H. (2008, November 24). Coronary heart disease epidemiology: global context for a new genetic understanding [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved February 9, 2025, from https://doi.org/10.69645/HUSF1205.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Harry Hemingway has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Coronary heart disease epidemiology: global context for a new genetic understanding
Published on November 24, 2008
23 min
A selection of talks on Genetics & Epigenetics
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