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1. Introduction
2. Overview
3. Section 1
4. CVD burden increasing globally
5. CVD mortality increases rapidly within generation
6. The epidemiological transition
7. Stages of epidemiological transition and CVD
8. Global burden of disease study 2030 projections
9. Where are most CHD deaths occurring?
10. Diabetes and CVD death rates in EME and India
11. Rate of CHD decreases in the UK
12. Within/between country geographical variations
13. Age as a risk factor
14. CHD death rates by social class
15. Interheart: MI case control study in 52 countries
16. Interheat conclusions
17. Obesity trends in US adults BRFSS, 1986 - 2003
18. We know how to prevent CHD
19. Shifting the population distribution of risk
20. Summary (1)
21. Section II: possible relevance of genes
22. Two examples
23. Sex/gender
24. Deaths by cause in European women
25. Male excess in coronary death in 52 countries
26. What about other coronary phenotypes?
27. Time trends in angina and MI
28. Sex differences in angina prevalence
29. Angina: no male excess across 31 countries (1)
30. Angina: no male excess across 31 countries (2)
31. So what?
32. Finland: whole population clinical epidemiology
33. Sex differences in angina incidence: Finland
34. Effect of angina on CHD mortalilty
35. Genome wide association studies
36. Phenotypes in WTCCC GWAS
37. GWAS: MI vs. CAD without MI
38. Genetic influences on smoking behaviour
39. Genotype and smoking quantity: Iceland
40. Same effect in Spain and the Netherlands
41. Genotype, lung cancer and PAD
42. Study conclusions
43. Summary (2)

Topics Covered

• Established importance of environment factors
• CVD burden increasing globally
• Rapid within generation increase in CVD mortality rates
• The epidemiological transition
• Stages of epidemiological transition and CVD
• Where in the world are most CHD deaths occurring?
• Within and between country geographical variations
• Age is the strongest risk factor for CVD
• CHD deaths by social class
• Interheart
• Obesity trends
• We know how to prevent CHD
• Shifting the population distribution of risk
• Possible relevance of genes
• Large scale epidemiological evidence
• Deaths by cause in women
• Coronary phenotypes
• Angina trends
• Evidence from Finland
• Genome-wide association studies
• Phenotypes in WTCCC GWAS
• Genetic influences on smoking behavior
• Genotype and smoking quantity
• Phenotypically differentiating chronic and acute syndromes of coronary disease is likely to be important
• Interplay between identified genetic variants and environmental exposures in large scale studies: watch this space

Links

Series:

• Genetics of Cardiovascular Disease

Categories:

• Clinical Practice
• Genetics & Epigenetics

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Hemingway, H. (2008, November 24). Coronary heart disease epidemiology: global context for a new genetic understanding [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 23, 2024, from https://doi.org/10.69645/HUSF1205.
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Publication History

• Published on November 24, 2008

Financial Disclosures

• Prof. Harry Hemingway has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.