• Perspective and Pathogenesis
• 23 min
  1. Expanding frontiers of cerebrovascular disease

  • Prof. Vladimir Hachinski
• 32 min
  2. Basic anatomy, physiology and pathophysiology of the cerebral circulation for the physician

  • Prof. Jean-Claude Baron
• 43 min
  3. Pathophysiology of cerebral ischemia

  • Prof. Wolf-Dieter Heiss
• 20 min
  4. Intracerebral hemorrhages: causes and clinical findings

  • Prof. Louis Caplan
• 40 min
  5. Subarachnoid hemorrhage (SAH)

  • Prof. R. Loch Macdonald
• Diagnosis
• 32 min
  6. Clinical diagnosis of stroke and subtypes

  • Prof. Louis Caplan
• 30 min
  7. The investigation of stroke

  • Dr. Bart Demaerschalk
• Treatment
• 35 min
  8. Acute therapy of stroke and reperfusion treatments

  • Prof. Brian Silver
• 39 min
  9. Subarachnoid hemorrhage diagnosis and management

  • Prof. Gary K. Steinberg
• 26 min
  10. Stroke-induced heart injury

  • Dr. Luciano A. Sposato
• Rehabilitation
• 37 min
  11. Stroke rehabilitation: principles of stroke

  • Prof. Robert Teasell
• 27 min
  12. Stroke rehabilitation: therapies and treatments

  • Prof. Robert Teasell
• Prevention
• 23 min
  13. Lifestyle and nutrition in stroke prevention

  • Prof. J. David Spence
• 40 min
  14. Prevention: carotid endarterectomy, angioplasty, and stenting

  • Prof. Brian Hoh
• Special Topics
• 54 min
  15. Pediatric stroke: cerebrovascular injury in the developing brain

  • Prof. Adam Kirton
• 43 min
  16. Stroke in women: epidemiology, risk and prevention

  • Prof. Cheryl Bushnell
• 25 min
  17. Transient ischemic attack and cognition

  • Dr. Jennifer Mandzia
• 31 min
  18. Vascular cognitive impairment

  • Prof. Eric E. Smith
• 34 min
  19. Atrial fibrillation, anticoagulation and vitamins for homocysteine

  • Prof. J. David Spence
• 41 min
  20. Stroke in the young adult

  • Prof. Jeffrey Saver
• 16 min
  21. Stroke in the young

  • Dr. Gyan Kumar
• 23 min
  22. Convergence and joint prevention of stroke and dementia

  • Prof. Vladimir Hachinski
• Archived Lectures *These may not cover the latest advances in the field
• 55 min
  23. Vascular cognitive impairment

  • Dr. John Bowler
• 32 min
  24. Pediatric stroke

  • Dr. Gabrielle deVeber
• 36 min
  25. The deteriorating stroke

  • Prof. Werner Hacke
• 27 min
  26. General management

  • Prof. Bo Norrving
• 35 min
  27. The treatment of stroke: specific management - thrombolysis plus

  • Prof. Nils Wahlgren
• 42 min
  28. Rehabilitation: the chronic phase

  • Prof. Lalit Kalra
• 61 min
  29. Prevention: management of risk and protective factors

  • Prof. Graeme Hankey
• 30 min
  30. Medical therapy for secondary prevention of ischemic stroke

  • Prof. Larry Goldstein
• 34 min
  31. Subarachnoid haemorrhage

  • Prof. Jan van Gijn
• 35 min
  32. Controversies in stroke

  • Prof. Stephen Davies
  • Prof. Geoffrey Donnan
• 35 min
  33. Medical and surgical stroke

  • Prof. Carlos Kase
• 35 min
  34. The urgency of stroke prevention after TIA

  • Prof. S. Claiborne Johnston
• 54 min
  35. Carotid endarterectomy, angioplasty and stenting

  • Prof. Martin Brown
• 42 min
  36. The clinical diagnosis of stroke and stroke subtypes

  • Prof. Louis Caplan

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Introductory remarks
3. The deteriorating IS - content
4. Causes of early deterioration after IS (1)
5. Causes of early deterioration after IS (2)
6. Causes of early deterioration after IS (3)
7. Pathophysiology of ischemic brain edema
8. Edema formation after ischemic stroke
9. Treatment of brain edema
10. Pathophysiology of space occupying infarction (1)
11. Pathophysiology of space occupying infarction (2)
12. Delay of edema-formation and ICP-elevation
13. Malignant MCA infarction
14. Early neurologic death after stroke (1)
15. Complete MCA-infarction imaging
16. Herniation imaging
17. Early neurologic death after stroke (2)
18. Clinical course
19. Early diagnosis of malignant MCA infarction
20. Early infarct signs
21. Natural history and early diagnosis
22. Malignant MCA and brain edema
23. ICU care for ischemic stroke
24. Baseline therapy in severe stroke
25. ICP-therapy in stroke (1)
26. Medical therapy
27. ICP-therapy in stroke (2)
28. Hypothermia
29. Hypothermia - trauma and cardiac arrest
30. How to cool the brain?
31. Hypothermia side effects
32. Hypothermia - influence on edema formation
33. ICP-therapy in stroke (3)
34. Decompressive surgery - technical aspects
35. Peri-operative ICU treatment
36. Results of decompressive surgery
37. History of decompressive surgery
38. The prospective cohort series (1)
39. The prospective cohort series (2)
40. Meta-analyses and registries
41. The controversy - predictors of outcome
42. The controversy - survival vs. quality of life
43. The reality of randomized trials for rare conditions
44. The 5 randomized clinical trials (1)
45. The 5 randomized clinical trials (2)
46. The pooled analysis - DESIRE
47. Design of the pooled analysis (1)
48. Design of the pooled analysis (2)
49. Design of the pooled analysis (3)
50. Results - distribution of outcome
51. Results - primary endpoint
52. Conclusions
53. Open questions (1)
54. Timing of decompressive surgery
55. Timing (1)
56. Timing (2)
57. Open questions (2)
58. DESIRE- pooled analysis
59. Do we need more evidence from further RCTs?

Topics Covered

• Causes of stroke
• Pathophysiology of ischemic brain edema
• Space occupying infarction
• Treatment of ischemic brain edema
• Causes of early deterioration after ischemic stroke
• Large, space occupying edema
• Edema formation after ischemic stroke
• Treatment of brain edema
• Pathophysiology of space occupying infarction
• Delay between edema formation and ICP-elevation
• Malignant MCA infarction
• Clinical course
• Natural history and early diagnosis
• Malignant MCA and brain edema
• Conservative treatment options
• ICU care for ischemic stroke
• Baseline therapy in severe stroke
• ICP therapy in stroke
• Medical therapy
• Hypothermia
• Decompressive surgery
• The controversy: survival vs. quality of life
• The reality of randomized trials for rare conditions
• The 5 RCTs
• Pooled analysis design
• Results
• Timing
• The need for more evidence for the general approach and not the details

Links

Series:

• Cerebrovascular Disease

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on October 27, 2008
• Archived on June 22, 2016

Financial Disclosures

• Prof. Werner Hacke has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.