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1. Introduction
2. The secretory pathway
3. The endoplasmic reticulum
4. Chinese hamster ovary cell
5. Factor VIII expression induces ER stress
6. Protein folding
7. The Unfolded Protein Response (UPR)
8. Processes regulated by the UPR
9. UPR signaling responses
10. Activation of the unfolded protein response (1)
11. Activation of the unfolded protein response (2)
12. Stress signaling from the endoplasmic reticulum
13. Role of eIF2 in translation initiation
14. Translation initiation response to external stimuli
15. Translation attenuation by PERK
16. eIF2 phosphorylation and translation attenuation
17. eIF2 phosphorylation is required for UPR
18. UPR transcriptional activation by ATF4
19. Wolcott-Rallison syndrome
20. IRE1 pathway for UPR activation
21. Unspliced and spliced forms of XBP1
22. Morphology of ire1 wild-type and null embryos
23. Plasma cell differentiation requires ER expansion
24. IRE1alpha / XBP1 role in lymphocyte development
25. Model for UPR role in B-cells differentiation
26. ATF6 pathway for UPR activation
27. Regulated Intramembrane Proteolysis (RIP)
28. ATF6 and CREBH have similar domain structures
29. Induction of acute phase response
30. Tripartite stress signaling from the ER
31. Activation of stress signaling from the ER
32. IRE lumenal domain
33. IRE1 lumenal domain dimer
34. ER stress-induced apoptosis
35. ROS and disulfide bond formation
36. ER stress and oxidative stress
37. Life or death upon unfolded proteins accumulation
38. ER perturbation by mild stress
39. UPR pathways outcomes during persistent stress
40. UPR-induced alterations in gene expression
41. Summary

Topics Covered

• The secretory pathway
• Factor VIII expression induces ER stress
• Protein folding: the ultimate and most error prone step in gene expression
• The "unfolded protein response" (UPR) ensures fidelity of protein folding
• UPR signaling response
• Activation of the UPR
• Stress signaling from the ER
• Role of eIF2 in translation initiation
• Translation initiation response to external stimuli
• eIF2a phosphorylation is required for UPR
• Wolcott-Rallison syndrome
• Plasma cell differentiation requires ER expansion
• Roles of IRE1a/XBP1 in lymphocyte development
• ER-stress-induced transcription through regulated intramembrane proteolysis (RIP)
• CREBH and ATF6
• ER-stress-induced apoptosis
• ER stress and oxidative stress
• UPR-induced alterations in gene expression

Links

Series:

• The Endoplasmic Reticulum

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Kaufman, R. (2007, October 1). The endoplasmic reticulum: the unfolded protein response [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/WLGN9400.
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Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Randal Kaufman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.