Neurotransmitter receptor auxiliary subunits

Published on December 31, 2023   38 min

A selection of talks on Physiology & Anatomy

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0:00
Hello everybody. My name is Javier Diaz Alonso, and I am an assistant professor at the Department of Anatomy and Neurobiology in the School of Medicine of the University of California, Irvine. Work in my lab focuses on the molecular mechanisms underlying synapse organization, transmission, and plasticity. We're particularly interested in two fascinating signaling systems which enable communication between neurons, and are critical for cognitive and emotional processes. The glutamatergic and endocannabinoid signaling systems. In this talk, I will provide a general overview of neurotransmitter receptor auxiliary subunits. This is a broad exciting topic which has evolved quickly during the past two decades, and has attracted neuroscientists from many disciplines. Biochemistry, biophysics, electroneutrality, imaging, and also more recently, medicinal chemists and drug development. Working as a post doc with Dr. Roger Nicoll at UCSF and now in my independent laboratory at UC Irvine, we have made some contributions to this topic, which we will discuss in this talk, along with crucial contributions from other laboratories.
1:10
Before we start diving into the main topic, I would like to draw your attention to some of the fantastic talks in this Henry Stewart collection, which are highly relevant to the materials covered in this talk, which I strongly recommend you to explore. These include but are not limited to, Dr. Stuart Cull-Candy on AMPA receptors and fast synaptic transmission in the brain. Dr. Johannes Hell on PSD-95, dynamic localization of PSD-95 and glutamate receptors at postsynaptic sites, and also a second talk on PSD-95, structural aspects of PDZ domain binding. Dr. Graham Collingridge on glutamate receptor modulation and long term synaptic plasticity. And Dr. Jonathan Hanley on postsynaptic scaffold proteins in health and disease. There's many other very good talks, but these are very relevant to the topics that we're covering today.

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Neurotransmitter receptor auxiliary subunits

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