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Printable Handouts
Navigable Slide Index
- Introduction
- Welcome!
- Disclosures
- Questions
- Refractory chronic migraine
- Definition: WHS 'simple definition'
- Definition: WHS 'complex definition'
- WHS 'complex definition': who is it for?
- Our definition includes: non-medication approaches
- Definition: geography
- Definition: other issues to consider (1)
- Definition: other issues to consider (2)
- Pathophysiology
- Pathophysiology: MOH and psych comorbidities
- RCM scale
- MOH: poorly defined, overdiagnosed
- Addressing MOH
- Outside of medications
- Key non-medication concepts
- Outside of medicine: acceptance, coping and functioning
- Caretakers and headache doctors
- Headache providers
- Outpatient therapy options
- Factors that influence treatment decisions
- Top ten therapies
- Selected outpatient options for refractory migraine
- When would we go to 'refractory' approaches
- OnabotulinumtoxinA
- OnabotulinumtoxinA: 'chase the pain'
- CGRP monoclonal antibodies
- Gepants
- Polypharmacy
- Medical cannabis: upsides
- Cannabis: the downsides
- SPG blocks - for frontal pain
- Trigger point acupuncture
- Nerve blocks and trigger point injections
- Frequent triptans
- Opioids
- Opioids: rules for success with opioids
- Stimulants: what can they help with?
- Stimulants
- Monoamine Oxidase Inhibitors (MAOIs)
- MAOIs: phenelzine, emsam patch, selegiline
- Going back to past medications
- Miscellaneous: methylergonovine and memantine
- Miscellaneous: muscle relaxants
- Ketamine
- Miscellaneous: neuromodulation
- Miscellaneous: non-invasive neuromodulation
- Neuromodulation devices
- Surgical procedures
- Should we ever 'give up' on a patient?
- Thank you for listening
- References
Topics Covered
- Refractory chronic migraine
- Medical and non-medical approaches to refractory migraine treatment
- Migraine preventives
- Migraine abortives
- Medication Overuse Headache (MOH)
- Factors that influence migraine
- Treatment approaches
- Opioids
- Stimulants
- Neuromodulation
Links
Categories:
Therapeutic Areas:
External Links
Talk Citation
Robbins, L. (2023, November 30). Refractory migraine [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/XLQE1920.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Robbins is a speaker for Abbvie.
A selection of talks on Neurology
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, I'm Larry Robbins.
The talk today is
Refractory Migraine.
0:07
You can always email me at
Irobb98@icloud.com and
I've been involved in
publishing and
writing guidelines
for Refractory
Migraine for 22 years.
Recently and I'll go over,
we have some new guidelines
through the World
Headache Society.
Videos of this talk
are also on VuMedi.
I have a Youtube channel
with a lot of videos too
that are related and
you can reach me.
This talk is updated,
the one today.
The previous talks that I
have on the Internet are
a year, two, three
years old and things
get out of date in Refractory
Migraine fairly quickly.
0:52
I'm a speaker for Abbvie,
it should not
influence this talk.
0:57
Some questions that will go
over is 'Medication
Overuse Headache (MOH)
easy to identify,
but difficult to
treat' and it's not
so easy to identify.
It's often conflated with
medication overuse and
I'll go over that.
Number 2, 'Migraine surgery
is a reasonable option'.
That's not true, in my opinion.
I think the jury is
still out although
posterior decompression surgery
is a reasonable option.
'Comorbidities often determine
where we go with therapy'.
That's absolutely true.
They drive where we go.
Number 4, 'onabotulinumtoxinA,
trade name is Botox,
is our third best preventive,
and that 155 units is the only
dose', and that's not true.
We chase the pain,
we do various doses.
It's really probably
our best preventive
overall, considering
safety and efficacy.
Finally, 'resilience has
a strong genetic component',
is absolutely true.
Long arm and short arm of
serotonin transporter
gene is crucial.