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1. Introduction
2. Overview
3. Ca sources
4. Ca oscillations in smooth muscle
5. Ca signals triggering factors
6. Store-operated Ca entry (SOCE): an enigma
7. SOCE: the discovery of Stim1 and Orai1
8. SOCE: STIM1 clustering
9. SOCE: molecular basis for Ca entry
10. Ca signaling to the nucleus
11. Ca channel signaling to the nucleus
12. Ca-regulated transcription factors
13. CREB transcription factor
14. CREB: activation domains
15. CREB: signaling cascades
16. CREB: transcriptional activation
17. Ca regulated transcription factors: NFAT
18. NFAT: activation domains
19. NFAT: signaling cascades
20. SOCE leads to CREB and NFAT activation
21. L-type Ca signaling to CREB and NFAT
22. SRF transcription factor
23. Ca, SRF and smooth muscle cell differentiation
24. Examples of SRF-mediated phenotype switiching
25. Ca and smooth muscle cell gene transcription
26. Store-operated Ca and autoimmune disease (1)
27. Store-operated Ca and autoimmune disease (2)
28. Ca-regulated gene transcription and disease
29. Ca-regulated gene transcription and hypertrophy
30. Role of calcineurin and NFAT in hypertrophy
31. Role of NFAT in development of cardiac valves
32. NFAT co-factor MEF-2 plays a role in hypertrophy
33. Future clinical implications
34. CREB and CNS function
35. CREB is a central responder to neuronal inputs
36. Loss of CREB results in multiple neuronal defects
37. CREB and clinical implications
38. CREB and hypertensive disease
39. Ca signals lead to CREB activation
40. Ca signaling increases CRE-containing genes
41. Hypertensive disease raises CREB phosporylation
42. Hypoxia reduces CREB expression
43. Summary

Topics Covered

• Calcium sources
• Calcium-regulated transcription factors: Calcium/cAMP response element binding protein (CREB), nuclear factor of activated T-cells (NFAT) and serum response factor (SRF)
• Calcium signaling cascades
• Calcium and cell differentiation
• Calcium and disease

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007
• Updated on September 22, 2013

Financial Disclosures

• Dr. Karen Lounsbury has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.