Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Calcium signals and waves
3. Signal transduction via Ca2+
4. Cells utilise different sources of Ca2+ for signaling
5. Ca2+ release pathways
6. Ca2+ signalling via NAADP and cADPR
7. Store-operated Ca2+ entry
8. Calcium 'on' and 'off' mechanisms
9. Ca2+ acts in different time domains
10. Ca2+ signals can have different frequencies
11. Ca2+ signals can have varying amplitudes
12. Different spatial dimensions of Ca2+ signals
13. Ca2+-induced gene transcription
14. Neuronal development encoded by Ca2+ signals
15. Different cells express varying 'toolkit' components
16. Ca2+ signalsomes undergo self-assessment
17. Cells express multiple Ca2+ release pathways
18. The phosphoinositide signal transduction pathway
19. Inositol 1, 4, 5-trisphosphate receptors
20. InsP3 receptors are located on the ER
21. Mitochondrial calcium uptake monitoring
22. The mitochondrial Ca2+ uptake pathway
23. Mitochondrial calcium uptake and the Krebs cycle
24. Mitochondrial calcium uptake leads to apoptosis
25. InsP3 receptors accelerate apoptosis
26. InsP3 receptors bind multiple accessory proteins
27. Bcl-2 "B cell lymphoma-2"
28. Bcl-2 reduces InsP3 receptor activity
29. Bcl-2 suppresses InsP3-induced Ca2+ release
30. Calcium and apoptosis
31. Cells express multiple Ca2+ release pathways
32. Excitation-contraction coupling in cardiac muscle
33. Ca2+ underlies excitation-contraction coupling (1)
34. Inhomogeneous Ca2+ signals in atrial muscle (1)
35. Inhomogeneous Ca2+ signals in atrial muscle (2)
36. Ca2+ underlies excitation-contraction coupling (2)
37. Atrial myocyte Ca2+ channel distribution
38. Atrial myocyte excitation-contraction coupling (1)
39. Ca2+ underlies excitation-contraction coupling (3)
40. Physiological sympathetic inotropy stimulation
41. Isoproterenol increases cellular contraction
42. Endothelin-1 increases atrial cell contractility
43. Endothelin-1 causes positive inotropy
44. Positive inotropy and increased contraction in atria
45. Atrial myocyte excitation-contraction coupling (2)
46. Endothelin-1 causes inotropy and arrhythmias
47. Endothelin-1 evokes spontaneous Ca2+ transients
48. Dysrhythmias and spontaneous Ca2+ release
49. Atrial myocyte at rest
50. Atrial myocyte showing spontaneous Ca2+ sparks
51. Spontaneous calcium signals cause depolarisation
52. Further reading

Topics Covered

• Introduction to the spatial and temporal complexity of cellular calcium signals
• Calcium 'on' and 'off' mechanisms
• The calcium signaling toolkit
• Calcium sources
• Calcium waves
• Calcium oscillations
• Cell-specific calcium signaling proteomes
• Examples of calcium signaling differentially controlling cellular processes such as gene transcription and neuronal differentiation
• Inositol 1,4,5-trisphosphate receptors as an example of a calcium release system
• Mitochondrial calcium uptake
• Regulation of apoptosis by calcium
• Cardiac calcium signaling
• Atrial myocytes regulate contraction by modulating the spatial properties of their calcium signals
• Calcium-induced arrhythmias

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007
• Updated on July 15, 2012

Financial Disclosures

• Dr. Martin Bootman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.