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Printable Handouts
Navigable Slide Index
- Introduction
- How do we know the structure of DNA?
- Gross structure – the chromosome
- What forms the chromosome?
- The DNA helix
- The structure of DNA at a chemical level
- What holds DNA together?
- Van der Waals non-covalent bonds
- The distribution of partial charge
- Pi stacking - a special Van der Waal
- Hydrogen bonds
- Hydrogen bond energetics
- Hydrogen bond directionality (1)
- Hydrogen bond directionality (2)
- Amino acid side chain hydrogen bonding
- Salt bridges
- The hydrophobic effect
- Reading' the DNA sequence
- Zinc fingers
- Zinc finger interactions
Topics Covered
- The structure of DNA
- Types of binding between molecules
- Van der Waals non-covalent bonds
- Hydrogen bonds
- Amino acid side chain hydrogen bonding
- Salt bridges
- Zinc fingers
Talk Citation
Houston, D. (2019, May 30). The biochemistry of DNA and RNA 1: chemistry [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 31, 2024, from https://doi.org/10.69645/TGBF5287.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
The biochemistry of DNA and RNA 1: chemistry
Published on May 30, 2019
36 min
A selection of talks on Genetics & Epigenetics
Transcript
Please wait while the transcript is being prepared...
0:00
Welcome everyone. My name is Dr. Douglas Houston.
I'm a senior lecturer at the University of Edinburgh.
Today I'm going to be talking about "The Biochemistry of DNA and RNA".
The lecture is split into two parts.
The first part will be zooming right in on the chemistry of these molecules,
and then for the second part,
we will be looking at the relevance of this chemistry
to the biological function of these molecules.
So Part 1.
0:35
Just to introduce to you a little bit of history behind the structure of DNA.
The structure of DNA was first elucidated or discovered in 1953, or at least,
that's when the famous paper was published by Watson and Crick,
two scientists who you might have heard of,
but also with a lot of input from another scientist called Rosalind Franklin.
They used a technique called X-ray diffraction to
essentially measure the repeating pattern in the structure of DNA.
So it's similar to a technique called X-ray crystallography,
which you may have heard about.
But this was a rather more old-fashioned technique that didn't require crystals.
It's actually fiber diffraction.
They actually were able to deduce from
the diffraction spots on a photographic film caused by the diffraction of X-ray waves,
this repeating pattern, and from that,
they were able to build a molecular model of
how the various chemical components of the polymer fit together.
This first half of the lecture,
we'll be talking a lot about the specifics of how
these different parts of the molecule interact.