Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Genetic association
3. Genotype notation
4. Allele notation
5. One-locus association
6. Inbreeding coefficient
7. Multiple alleles
8. Hardy-Weinberg testing
9. Power of HW test
10. Two-locus association
11. Linkage disequilibrium testing
12. HW, LD statistics comparison
13. Variance of HW, LD statistics
14. Estimating gamete frequencies
15. EM algorithm
16. Composite disequilibrium
17. Composite LD estimate
18. General disease model
19. Disease associations
20. Detecting association with HWD
21. Case-control comparison
22. Case-control test
23. Contingency-table tests
24. Populations not in HWE
25. Haplotype associations
26. Haplotype association parameter
27. Four-locus association
28. Four-locus LD
29. Three-locus LD test
30. Three-locus test partition
31. Two-locus normal-based test
32. Three-locus normal-based test
33. Two-locus LD bounds
34. Two-locus bounds example
35. Three-locus bounds
36. Four-locus bounds
37. References
38. Acknowledgements

Topics Covered

• Alternative methods of estimating and testing hypotheses
• Causes and description of departures from independence of alleles at one, two or three loci
• Effects of multiple alleles
• Comparison of allelic and genotypic association tests in the case-control setting
• Trend tests

Links

Series:

• Genetic Epidemiology I

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Weir, B. (2004, September 1). Statistical characterization of genetic association [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 26, 2024, from https://doi.org/10.69645/REEB6117.
Export Citation (RIS)

Publication History

• Published on September 1, 2004
• Archived on February 25, 2021

Financial Disclosures

• Prof. Bruce Weir has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.