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0:00
Hi, my name is David Seder,
I'm a Critical Care Specialist
at Maine Medical Center
in Tufts University in Portland, Maine.
And I'm going to be
speaking to you today
about the Post-Resuscitation Syndrome
after Cardiac Arrest.
0:16
I have no financial conflicts
to disclose,
I do have investment
in cardiac arrest research,
and I have an unpaid volunteer position
with The International
Cardiac Arrest Registry.
0:30
When the heart stops,
when a patient develops a cardiac
or cardiopulmonary arrest,
the brain and other organs
do not receive blood flow
and they begin to die.
And even if the heart can be restarted
and circulation restored,
there is often a fatal injury
to the brain
or a fatal cascade of events
that leads to the patient's death.
And one of the sad facts
of cardiac arrest
is that most patients
who are successfully resuscitated
from cardiac arrest do not survive
or recover from their injuries.
1:06
After resuscitation, cells in the organs
including heart, lungs, brain, kidneys,
liver, etc begin to die.
Bacteria enter the bloodstream
from the intestines,
inflammation surges
throughout the body,
and this constellation of symptoms
and physiologic derangements
is called
the post-resuscitation syndrome
or post-resuscitation disease.
1:34
This is not a new concept,
the first mention of this,
that I'm aware of, in the literature
is from 1972.
And this is actually
from the very first issue
of the journal Resuscitation
in which a Soviet physician describes
a 'post-resuscitation disease'
occurring in animal models
of cardiac arrest.
And his editorial
in this journal suggests
that we should be targeting
this post-resuscitation disease
as a second step
of resuscitation treatment.
