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1. Introduction
2. Definitions
3. Nomenclature
4. Polymorphism types
5. Polymorphisms in human gene pool
6. Discovery of microsaellite polymorphisms
7. Evidence of polymorphisms in human CA repeats
8. Genotyping microsatellite polymorphisms
9. Complications of microsatellite analysis
10. Non-integer alleles
11. Strand slippage
12. Instrumentational improvement in genotyping
13. Microsatellite genotyping output and cost
14. Three basic microsatellite repeats
15. Alternative names
16. Distribution of STRs in whole human genome
17. Diallelic short insertion/deletion polymorphisms
18. Abundances of mono- and dinucleotide repeats
19. Abundances of tri- and tetranucleotide repeats
20. Applications of microsatellites
21. Linkage disequilibrium
22. STRP pairs showing allelic association
23. Geoancestry of subjects from Dominican Republic
24. Autozygous detection segments of chromosome 6
25. Microsatellite mutation
26. Informativeness of (CA)n versus number of repeats
27. Microsatellite mutation events
28. Distribution - mutation rate vs. repeat length
29. Delta values versus repeat length
30. Polymorphisms in human gene pool
31. Biological function of microsatellites (1)
32. Trinucleotide repeat diseases
33. Biological function of microsatellites (2)
34. Evolution of microsatellites
35. A-rich microsatellites from retroposon poly-A tails
36. Allele frequency distribution - ACT1A01
37. Allele frequency distribution - AFM002zf1
38. Human minisatellites
39. Canonical minisatellites

Topics Covered

• Microsatellites: nomenclature and definitions
• Discovery
• Typing methodology
• Abundance and types
• Applications
• Mutation
• Biological functions
• Evolution
• Minisatellites

Links

Series:

• Human Population Genetics I

Categories:

• Genetics & Epigenetics

Talk Citation

Weber, J. (2007, October 1). Human microsatellite and minisatellite DNA polymorphisms [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 26, 2024, from https://doi.org/10.69645/HVNB6098.
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Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Dr. James Weber has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.