Please wait while the transcript is being prepared...
0:00
Welcome to Pharmacometrics
in Tuberculosis.
My name is Chuck Peloquin.
I'm a professor at the University
of Florida College of Pharmacy
and the University of Florida
Emerging Pathogens Institute.
Today, we'll be talking about
the drugs that are used to treat
tuberculosis and some other key
features to using them properly.
0:23
Slide two shows the drugs
that are FDA, or Food and Drug
Administration, approved for
treatment of tuberculosis
in the United States.
Very similar lists of drugs
are available in countries
around the world.
Some countries have more limited
formularies, and the second line
drugs, and we'll
discuss what that means,
are available through
programs offered
by the World Health
Organization, or WHO.
Aminosalicylate, also known
as aminosalicylic acid or PAS,
is the oldest of the TB drugs,
discovered in the early 1940s
in Sweden, and that was followed
very shortly by the discovery
of streptomycin, the first
of the aminoglycosides.
The third TB drug to be
introduced was isoniazid, or INH,
and with the introduction
of isoniazid,
true combination therapy that
was actually quite effective
now was possible, and that
was in the early 1950s.
Continuing down the list from the
top, capreomycin is a polypeptide.
It's also an injectable
drug like streptomycin,
so there is no oral dosage form.
We'll talk a little bit more
about all of these drugs
in subsequent slides.
Cycloserine also is
considered a second line
drug, as is ethionamide.
Ethambutol, pyrazinamide,
rifampin, and rifapentine all
can be considered first line drugs.
