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Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Basal ganglia – thalamocortical loop
- The role of dopamine in Parkinsonism
- Methods for studying oscillatory activity (1)
- Methods for studying oscillatory activity (2)
- Description of oscillatory activity patterns
- Abnormal firing patterns in Parkinsonism
- Oscillatory patterns of neurons in Parkinsonism
- Oscillatory neuronal firing patterns in humans
- EEG abnormalities in Parkinson’s disease (PD)
- LFP oscillations in Parkinson’s disease
- LFP recordings in STN and GPi in PD patients
- Characteristics of oscillations
- Oscillations in the basal ganglia of PD patients
- Oscillatory activity involves multiple neurons
- Oscillatory activity in the thalamus
- Oscillatory activity in motor cortex
- Electrocorticogram recordings in PD patients (1)
- Electrocorticogram recordings in PD patients (2)
- Electrocorticogram recordings in PD patients (3)
- Oscillatory frequencies may differ
- Circuit-wide oscillations
- Cortex-basal ganglia coherence in PD patients
- Coherence analysis in MPTP-treated monkeys
- Cause(s) of oscillatory activity patterns
- Cause(s) of the emergence of oscillations in PD
- Link between oscillations and Parkinsonism
- Oscillatory interactions: cortex and basal ganglia
- Causal relationship between oscillations & PD (1)
- Causal relationship between oscillations & PD (2)
- Causal relationship between oscillations & PD (3)
- The case against a causal relationship (1)
- The case against a causal relationship (2)
- The case against a causal relationship (3)
- Use of oscillatory activity to assist/control DBS
- Summary
- Thanks
Topics Covered
- Basic anatomical functional facts in Parkinson’s disease
- Methods for studying oscillatory brain signals
- Oscillatory activity patterns in individual brain areas
- Circuit-wide oscillations
- Cause(s) of oscillatory activity patterns and the link to Parkinsonism
- Use of oscillatory activity to assist/control deep brain stimulation
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Talk Citation
Wichmann, T. (2022, January 7). Oscillatory neuronal activity patterns in Parkinson’s disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 17, 2024, from https://doi.org/10.69645/DJLQ4764.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Thomas Wichmann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Update Available
The speaker addresses developments since the publication of the original talk. We recommend listening to the associated update as well as the lecture.
- Full lecture Duration: 46:13 min
- Update Interview Duration: 12:21 min
A selection of talks on Neurology
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is Thomas Wichmann.
I'm in the Department of Neurology at Emory University in Atlanta.
The talk today will be about oscillatory neuronal activity patterns in Parkinson's disease.
0:14
Here's the outline of my talk.
I will first make you acquainted with some basic anatomical facts, and with
some of the methods that are being used to assess oscillatory brain signals.
We will then look at oscillatory activity patterns in Parkinson's disease in individual brain areas,
followed by a brief examination of larger network oscillations.
Towards the end of the talk, I will then discuss what we know about the cause of
these oscillatory patterns, and how they relate to Parkinsonism.
0:43
Before discussing details of the oscillatory patterning of brain activity in Parkinson's disease,
I'd like to introduce you to a few basic facts about the underlying brain circuitry.
The basal ganglia, thalamus, and cortex are thought to form larger loop structures, as you can see in this slide.
These loops work as functional modules.
There are loops that are related to movement functions, while others are dealing with the control of executive functions or emotions.
This diagram shows you the so-called 'motor circuit'.
Functional abnormalities within this circuit are thought to underlie the motor problems in Parkinson's disease.
The striatum, consisting of putamen and caudate nucleus and the external palatal segments (GPe in this slide),
the subthalamic nucleus (STN), the internal segment of the globus pallidus (GPi) and the substantia nigra pars reticulata (SNr),
and the pars compacta of the substantia nigra (SNc), are the core basal ganglia structures.
The striatum and STN receive cortical input,
while the GPr and SNr provide output from the basal ganglia to the thalamus,
which then projects back to the cortex.
We will not further cover the internal connectivity of the basal ganglia that is shown here,
but it is important that the SNc, through release of its neurotransmitter dopamine
in the striatum and other circuit elements, is thought to regulate the flow of activity from
the input to the output stations of the basal ganglia.