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Printable Handouts
Navigable Slide Index
- Introduction
- Disclosures
- Atherothrombosis - clinical manifestations
- T2DM – equivalent of coronary artery disease
- Total and CVD mortality - 18 years of follow-up
- Mortality trends w & w/o diabetes (33 years FU)
- CHD risk equivalency and concomitant risk factors
- Cardiometabolic risk (ADA MCR Initiative)
- Coronary artery disease and diabetes
- Cardioprotection in DM-pharma. interventions
- Framingham heart study
- STENO 2 study: multifactorial intervention (1)
- STENO 2 study: multifactorial intervention (2)
- ADDITION: cumulative incidence of CV endpoints
- Screening for diabetes may be beneficial
- ADDITION: early multifactorial therapy in T2DM
- Joint EASD/ESC guidelines
- Platelet activation & inhibition by antiplatelet drugs
- Statins
- The AFFORD trial
- Risk reduction by LDL reduction&diabetic state (1)
- Risk reduction by LDL reduction&diabetic state (2)
- Effects on major vascular events
- Effects on major vascular events (by lipid profile)
- Primary prevention with statins in diabetes (1)
- Primary prevention with statins in diabetes (2)
- Primary prevention with statins in diabetes (3)
- The Cochrane review 2011
- Guideline recommendations
- BP lowering therapy (including RAAS inhibition)
- Antidiabetic effects of RAS blockade
- Assessing new onset diabetes: a meta-analysis
- Strategy of BP lowering therapy in DM
- Antihypertensive Txs in patients with T2DM
- Reducing BP: combination therapy & monotherapy
- The ACCOMPLISH study
- Antihypertensive therapy at 5 years
- BP & vascular risk in diabetes (UKPDS, 2000)
- Major renal outcome by baseline BP
- Lowering BP reduces renal events in T2DM
- ROADMAP trial
- Blood pressure control results (INVEST)
- SBP&CV event reduction with antihypertensive Tx
- Glucose lowering & diabetes complications
- UKPDS: risk reduction by intensive treatment
- UKPDS post-trial monitoring: legacy effect
- UKPDS post-trial monitoring: survival & MI
- Treatment protocols of CVD trials
- Glycemic control: a meta-analysis
- Watch out for potential severe downsides
- The ORIGIN trial (vs. other CV outcome studies)
- Patients with less than 1 hypo episode at 1 year
- Median FPG (conventional units)
- Median A1C levels
- Hypoglycemia and weight (6-7 years)
- Primary & secondary outcomes
- Additional outcomes
- First coprimary (subgroups)
- Pharmacotherapeutic options in T2DM
- Managing T2DM pts: cardiovascular considerations
- Arguments in favor of early combination therapy
- EASD/ADA position statement 2012
- Cardiovascular prevention in T2DM: conclusions
- Guidelines of the European Society of Cardiology
Topics Covered
- Diabetes mellitus as an equivalent of cardiovascular disease and secular trends of cardiovascular outcomes
- Multi-factorial therapy as the golden treatment paradigm for cardiovascular prevention
- Statins in primary and secondary intervention
- Blood pressure lowering therapy under inclusion inhibition of the rennin-angiotensin-aldosterone system
- Outcome evidence of blood glucose lowering therapy
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Standl, E. (2013, June 11). Cardiovascular prevention in type 2 diabetes [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/XJUT8747.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Eberhardt Standl, Speaker’s Bureau: Merck Serono, Merck MSD, Bayer-Schering.
A selection of talks on Metabolism & Nutrition
Transcript
Please wait while the transcript is being prepared...
0:00
Welcome to this
Henry Stewart Talk
on cardiovascular prevention
in type 2 diabetes.
My name is Eberdhard Standl, and
I'm working at the Munich Diabetes
Research Group at the
Helmholtz Center in Munich.
0:19
These are my disclosures.
0:24
We all know the clinical
manifestations of atherothrombosis
in people with type 2 diabetes are
abundant, and particularly at heart,
but also at the brain, at
the peripheral arteries
and also the renal arteries
and the abdominal aorta.
0:52
Indeed it has been found
that type 2 diabetes seems
to be an equivalent of
coronary artery disease.
Now this has been based
on this landmark study,
at the so-called East
West Study in Finland.
We are looking here,
and actually the study
has been performed in the 1980s
and early 1990s in Finland,
so actually last century.
And what we see here
on the right side,
diabetic patients with no
prior myocardial infarction
has a risk of around 20% over seven
years from myocardial infarction,
and this is more or less identical
with risk in non diabetics
with a prior myocardial infarction.
So in other words,
somebody with diabetes
is at the same risk
level than somebody
without diabetes with a
prior myocardial infarction.
Of course, on the far right
side, patients with diabetes
and a prior myocardial infarction
are at an enormously high risk.