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1. Introduction
2. Outline
3. The magnitude of the association
4. Current diagnostic criteria
5. Burden of diabetes in the US
6. The MRFIT study
7. Diabetes and CVD death rates
8. Age-adjusted rates of nonfatal MI and fatal CHD
9. The CHS study
10. The Framingham study
11. HRs for vascular outcomes and diabetes
12. HRs for coronary heart disease
13. HRs and other risk factors
14. Fasting blood glucose
15. Comparison of HRs for coronary heart disease
16. Glycated hemoglobin
17. Type I diabetes
18. DCCT EDIC trail
19. The EDC study population
20. Intensive therapy and HbA1c
21. Cumulative incidence of CVD
22. Cumulative 30 year incidences
23. The nature of the association
24. Natural progression of atherosclerosis
25. Cross section of a clotted artery
26. CVD and death in diabetes
27. Predictors of heart disease
28. Increased risk in patients with kidney disease
29. Changes in risk factors for nephropathy
30. Distribution of incident CAD cases
31. Dramatic change in mortality rates
32. The FinnDiane study
33. Validation of these results
34. Primary cause of death of Pittsburgh EDC study
35. Renal disease and CVD
36. GHb and CVD in diabetes
37. CAD in T1D
38. Fatal CAD by HbA1c and insulin dose
39. Nonfatal CAD by HbA1c and insulin dose
40. Association of glycemia with CVD in T1D
41. Insulin resistance in type 1 diabetes
42. Family history predicts CAD
43. Equation describing insulin sensitivity
44. Survival curve for CAD by IR status
45. 10 year prediction
46. Proposed mechanisms of CAD in T1D
47. Effect of cholesterol
48. linkage of diabetes, insulin resistance and CVD
49. Insulin resistance syndrome
50. Prevalence of NCEP metabolic syndrome
51. Metabolic syndrome increases risks
52. Metabolic syndrome is a secondary factor
53. Cardiovascular mortality and diabetes
54. Decline in mortality and diabetes
55. Survival after heart attack
56. Risk factors for CVD
57. The effect of glucose
58. The DeCode study
59. HbA1c as a predictor of the disease
60. Predictors of MI
61. HbA1c's association with heart diseases
62. The glucose stabilization hypothesis
63. Glycemia and plaques
64. Morphology of atherosclerosis
65. Haptoglobin (Hp)
66. The Hp genotype
67. Hp and HDL cholesterol
68. Human longitudinal studies
69. The HOPE trial
70. The ICARE trail
71. End point change with vitamin E
72. Hp genotype over 18 years of follow-up
73. Multivariate modeling
74. Hp predicts renal disease
75. Conclusions

Topics Covered

• Epidemiology
• Definition and the magnitude of association in Type 1 and Type 2 diabetes
• Pathology and pathogenesis
• Major risk factors for heart disease in type 1 diabetes, including renal disease, insulin resistance and glycemic control
• Major risk factors for heart disease in type 2 diabetes, including insulin resistance and glycemic control
• Haptoglobin genotype and heart disease risk in diabetes

Links

Series:

• Diabetes in Perspective

Categories:

• Clinical Practice
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on May 22, 2013

Financial Disclosures

• Prof. Trevor J. Orchard, Stock Shareholder (Self-managed): BMS intended stock.