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1. Introduction
2. What are ryanodine receptors?
3. Our cells are bathed in lethal amounts of calcium
4. Calcium-induced calcium release
5. Ryanodine receptor (RyR)
6. RyRs as signal integrators
7. Ryanodine receptors and disease
8. Porcine stress syndrome
9. Malignant hyperthermia (MH)
10. Central core disease (CCD)
11. CPVT
12. Ryanodine receptor in disease
13. Disease mutations cause a gain of function (1)
14. Disease mutations cause a gain of function (2)
15. Disease hot spots (1)
16. Disease hot spots (2)
17. The zipper hypothesis
18. CryoEM studies of the ryanodine receptor
19. Locating disease hot spots (1)
20. Locating disease hot spots (2)
21. Hot spots at high resolution
22. RyR crystallography (1)
23. RyR crystallography (2)
24. RyR1 (1-559)
25. Where is RyR1ABC located? (1)
26. Where is RyR1ABC located? (2)
27. Relationship to difference cryo-EM
28. Disease mutations (1)
29. Disease mutations (2)
30. Disease mutations (3)
31. Disease mutations (4)
32. Disease mutations (5)
33. Disease mutations (6)
34. Motions in the N-terminal hot spot
35. Working model
36. Unusual plasticity in the N-terminal hot spot
37. RyR2 delta exon3 (1)
38. RyR2 delta exon3 (2)
39. RyR2 delta exon3 (3)
40. RyR2 delta exon3 (4)
41. RyR2 delta exon3 (5)
42. RyR2 delta exon3 (6)
43. RyR2 delta exon3 (7)
44. Plasticity in RyR2A
45. Delta exon3 causes disease phenotype (1)
46. Delta exon3 causes disease phenotype (2)
47. Functional role of the rescue segment
48. Relationship to IP3 receptors
49. The inositol-1,4,5-trisphosphate receptor (IP3R)
50. The overall domain architectures are conserved (1)
51. The overall domain architectures are conserved (2)
52. Summary
53. Acknowledgements

Topics Covered

• Ryanodine Receptors and calcium release
• Disease mutations: malignant hyperthermia and cardiac arrhytmia
• Disease hot spots and their locations
• High Resolution structures: mutations and domain interfaces
• deletion of exon3
• Common allosteric mechanisms in IP3 receptors

Links

Series:

• Calcium Signaling II

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 31, 2012

Financial Disclosures

• Dr. Filip Van Petegem has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.