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1. Introduction
2. Apoptosis and programmed cell death
3. An example of cell death which is also apoptosis
4. Morphological changes during apoptosis
5. Apoptosis involves characteristic cellular changes
6. Occurrence of apoptosis
7. Induction of apoptosis
8. Caspases (1)
9. Caspase activation
10. Caspases (2)
11. Initiator caspase activation
12. Caspases (3)
13. Death folds
14. Inhibitor of apoptosis proteins
15. Apoptotic pathways in mammals
16. Mitochondrial pathway of apoptosis (1)
17. Release of cytochrome c
18. Apoptosome
19. Genetic evidence from knock-out mice
20. Mitochondrial outer membrane permeabilization
21. The Bcl-2 family proteins
22. Bcl-2 family proteins have similar structures
23. The pro-apoptotic proteins Bax and Bak
24. Activation and repression
25. Bcl-2 protein bound to BH3 peptide
26. Activation and de-repression
27. Bcl-2 "addiction"
28. Bid is activated by proteolytic cleavage
29. MOMP also promotes apoptosis inhibiting XIAP
30. Two types of MOMP
31. The mitochondrial permeability transition
32. Loss of mitochondrial membrane potential
33. Mice lacking cyclophilin D
34. Types of MOMP
35. Mitochondria undergo fission and fusion (1)
36. Mitochondria undergo fission and fusion (2)
37. Mitochondria fragment upon MOMP (1)
38. Mitochondria fragment upon MOMP (2)
39. Mitochondrial fission and MOMP
40. Caspase-independent cell death (CICD)
41. Cells die in the absence of caspase activation
42. CICD in the developing interdigital web
43. Mitochondrial pathway of apoptosis (2)

Topics Covered

• Apoptosis and programmed cell death
• Apoptosis occurrence and induction
• Role of caspase proteases in apoptosis
• Apoptotic pathways in mammals
• Mitochondrial pathway of apoptosis
• The Bcl-2 family proteins
• Mitochondrial permeability transition
• Bax/Bak "pore"
• Mitochondrial fission and outer membrane permeabilization
• Caspase-independent cell death

Links

Series:

• Mitochondrial Biogenesis

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on December 10, 2018

Financial Disclosures

• Prof. Douglas Green has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.