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1. Introduction
2. Overview
3. Prevalence
4. Neary criteria
5. Variants of FTD
6. Tau positive and tau negative variants
7. Tau immunopositive inclusions
8. Inclusions in sporadic ALS
9. Is FTD genetic?
10. Progranulin a new FTD gene
11. Progranulin haploinsufficiency
12. VBM analysis of FTLD with progranulin mutations
13. Progranulin gene structure
14. Progranulin highly expressed in peripheral blood
15. The syndrome
16. The region
17. The circuit
18. Cells, molecules and genes
19. FTD atrophy by clinical stage
20. Von Economo neuron (VENs) ACC and FI
21. VENs
22. Vens: vulnerable neuron in FTD?
23. Regions unique to individual behaviors
24. Overeating in FTD
25. Evolution of the "self"
26. Development of self - mirror studies
27. Development of self
28. Startle in FTD
29. Traditional frontal neuropsychology
30. Amyloid imaging
31. Research criteria for FTD
32. Conclusions
33. Acknowledgements

Topics Covered

• Prevalence and nomenclature of FTD
• The pathology of FTD (tau, TDP-43)
• The genetics of FTD (tau, progranulin)
• Patterns of atrophy and neuroanatomical correlates of behavior and cognition
• von Economo neurons
• Neuroimaging (amyloid imaging)
• Treatment

Links

Series:

• Neurodegenerative Diseases

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on February 14, 2010
• Archived on January 31, 2022

Financial Disclosures

• Prof. Bruce Miller has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.