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1. Introduction
2. Amount of sleep is characteristic of each species
3. Do all animals sleep?
4. Cuckoo bees stay anchored to a twig
5. Scorpions rest their head and claws on the ground
6. Crayfish lean to one side
7. Octopodes close their eyes
8. Quiescent period of box jellyfish
9. Paramecia are quiescent at night
10. Fruit flies are quiescent at night
11. Are these quiescent periods true sleep?
12. Behavioral criteria for sleep
13. Drosophila activity monitor
14. Ultrasound movement detector
15. Arousal threshold
16. Sleep rebound
17. Aging and sleep: humans
18. Aging and sleep: flies (1)
19. Aging and sleep: flies (2)
20. Cumulative sleep loss with caffeine
21. Effect of anti-histamines on sleep
22. Gene activity in sleep vs. waking
23. Sleep-regulated gene expression
24. Physiology of sleep in Drosophila
25. Local field potentials in sleep vs. waking
26. Nature of physiological activity in sleep vs. waking
27. Response to visual stimulus in sleep vs. waking
28. Sleep stages in mammals
29. Rapid eye movement (REM) sleep
30. Cycling of sleep stages through the night
31. Sleep recordings
32. A separate stage of sleep in Drosophila
33. Circadian rhythms and sleep
34. Sleep rebound in arrhythmic per0 mutant
35. Mortality in a rhythm mutant after sleep deprivation
36. Induction of stress genes can reduce mortality
37. Mortality of cys/hsp90 double mutant
38. Hsp90 is a “chaperone” protein
39. Response of neural mutants to sleep deprivation
40. Neuromodulators and sleep
41. Dopamine depletion increases fly sleep
42. Effect of metamphetamine on dopamine and sleep
43. Dopamine transporter mutant fumin
44. Expression of arylalkylamine N-acetyltransferase
45. Reactions catalyzed by AaNAT
46. Rebound in AaNAT mutant
47. cAMP mutants and sleep
48. PKA, mushroom bodies and sleep
49. Mushroom bodies and sleep
50. 5HT1A receptor in mushroom bodies affects sleep
51. Hypothalamus and SCN also regulate sleep
52. Key elements in the EGF pathway (Drosophila)
53. Secreted Egf-r ligand increases sleep
54. Loss of Egf-r signaling decreases sleep
55. Increase in sleep correlates with ERK activation
56. Distribution of active ERK in brain after heat shock
57. Expression of endogenous rho RNA and protein
58. ERK and pars intercerebralis expression pattern
59. Pars intercerebralis and hypothalamus
60. Hyperexcitability (Shaker mutant) and sleep
61. What is sleep for?
62. Metabolic replenishment
63. Synaptic homoeostasis
64. The glycogen theory of sleep
65. Examination of the glycogen theory in rats
66. Glycogen decreases during waking and deprivation
67. Glycogen levels differ among three mice strains
68. Changes in levels of protein synthesis genes
69. Closing remarks
70. Literature cited

Topics Covered

• Evolution of sleep
• Sleep-like behavior in Drosophila
• Physiological and pharmacological characteristics
• Genetics of sleep: neurotransmitter and signal transduction systems

Links

Series:

• The Legacy of Drosophila Genetics

Categories:

• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on September 29, 2008
• Reviewed on June 1, 2018

Financial Disclosures

• Dr. Ralph Greenspan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.