Topics Covered
- Pathology of diseases
- Prion diseases
- The first family with a prion mutation: Creutzfeldt-Jacob disease
- Alzheimer's disease
- 7Mb duplication of locus around APP
- APP probably a locus for "sporadic" Alzheimer's disease
- Diseases with only Lewy bodies: Parkinson's disease and Lewy body dementia
- Iowa kindred structure
- alpha-synuclein
- Diseases with only Tau pathology
- The microtubule associated protein tau
- Evolution of human tau haplotypes
- Tagging SNPs selection
- More complex than just H1/H2
- Association with PSP is driven by H1c allele
- Primary tauopathies
- "Prion-like " behaviour of A-beta
- Does the "spreading" of diseases reflect a less extreme version of infection?
- Alzheimer's disease is a neuroanatomical disease which "spreads"
- Parkinson's disease pathology also seems to spread
- MAPT and alpha-synuclein in the extracellular compartment?
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Hardy, J. (2008, September 4). Similarities between prion diseases and other neurodegenerative diseases [Video file]. In
The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 9, 2023, from
https://hstalks.com/bs/956/.
Export Citation (RIS)
Publication History
-
Published on September 4, 2008
Financial Disclosures
- Prof. John Hardy, Consultant: Eisai
Speaker's Bureau: Eli Lily
Grant/Research Support (Principal Investiqator): MRC/Wellcome Trust