• Introduction
• 30 min
  1. Prions and amyloids: introduction

  • Prof. Reed Wickner
• Mammalian Prions
• 26 min
  2. Transgenic mouse models of prion diseases

  • Prof. Glenn Telling
• 31 min
  3. Mechanism of prion generation in vitro

  • Dr. Surachai Supattapone
• Non-Prion Amyloids
• 48 min
  4. Similarities between prion diseases and other neurodegenerative diseases

  • Prof. John Hardy
• 43 min
  5. Molecular structure of amyloid and prion fibrils: insights from solid state NMR

  • Dr. Robert Tycko
• Yeast Prions
• 42 min
  6. Chaperones and prions

  • Prof. Yury Chernoff
• Beneficial Amyloids
• 52 min
  7. The dark side of amyloid: PMEL, a natural amyloid in melanosome biogenesis

  • Prof. Michael Marks
• Archived Lectures *These may not cover the latest advances in the field
• 41 min
  8. Predicting TSE transmission

  • Prof. Jean Manson
• 53 min
  9. Generation and propagation of infectious prions by cyclic amplification of protein misfolding

  • Prof. Claudio Soto
• 30 min
  10. Yeast and fungal prions: a help or a hindrance?

  • Prof. Reed Wickner
• 42 min
  11. [PIN+]: prions beget prions

  • Prof. Susan Liebman
• 36 min
  12. Yeast prions and protein chaperones

  • Dr. Daniel Masison
• 54 min
  13. Mechanisms of yeast prion propagation

  • Prof. Mick Tuite
• 31 min
  14. Propagation and variability of the yeast [PSI+] prion

  • Prof. Michael Ter-Avanesyan
• 43 min
  15. The genetics and biology of the [Het-s] prion of Podospora

  • Prof. Sven Saupe
• 33 min
  16. The structure of amyloid fibrils of the HET-s (218-289) prion as seen by solid-state NMR

  • Prof. Beat Meier

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Definition of prion and amyloid
3. Amyloid is usually a pathologic protein form
4. X-ray fiber diffraction
5. Amyloid structure
6. Amyloid fiber growth
7. Human disease-associated amyloids and prions
8. Useful amyloids
9. Prion classification
10. History of scrapie
11. Scrapie in ancient China?
12. Transmissible Spongiform Encephalopathies
13. Yeast and fungal prions
14. Discovery of genes later found to be prions
15. Three genetic criteria to identify a prion
16. [URE3] has the genetic properties of a prion
17. Comparison of prion domains
18. Prion is an infectious protein
19. Vacuolar protease B as a prion
20. Crippled growth of podospora anserina
21. MAP kinases as prions
22. Summery
23. Themes in prions and amyloidoses
24. References

Topics Covered

• Definitions of prions and amyloids
• Genetic criteria for a prion
• Prions of mammals, yeast and filamentous fungi
• Prion domains
• Non-amyloid prions

Links

Series:

• Prions and Amyloids

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on September 4, 2008

Financial Disclosures

• Prof. Reed Wickner has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.