Bioorganic studies of vision

Nakanishi, Koji

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Introduction
Structure of the eye
Visual pigments
Rhodopsin structure (1)
Rhodopsin structure (2)
Why 11-cis-retinal?
Terpenoid biosynthesis
Visual chromophores
Bioluminescent squid
The bovine rhodopsin
Activation of Rh and beta AR
Point charge model
Retinal / vitamin A cycle
Selective capture of retinoid binding proteins
Photocrosslinking of chromophore to Rh
Tracking the chromophore/opsin interaction
Rhodopsin photocycle
Photoaffinity labeling: DK-Lumi, seq. temp. - 80 C
An HPLC profile
Summary of the binding a.a. (1)
Summary of the binding a.a. (2)
Conformation determination of 11-cis-retinal
Chromophore conformation in Rh
Transient "dark activity" of 13-des-Me-retinal
Retinoids that form pigments
Photoaffinity- rhodopsin-G protein interaction
Age-related macular degeneration (AMD)
Age pigments or RPE lipofuscin
A2E fluorophore
A2E FAB-MS w/wo irr. blue light, 450 nm, 10 min
UV/vis spectra of oxo-A2Es
Formation of A2E, iso A2E and ATR dimers
A2- rhodopsin
ABCR- ATP binding cassette protein
Bilberry extract and A2E epoxidation
Anthocyanins
Acknowledgements

Topics Covered

Visual pigments
Visual chromophores
Activation of Rh and beta-AR
Retinal / vitamin A cycle
Selective capture of retinoid binding proteins
Photocrosslinking of chromophore to Rh
Tracking the chromophore / opsin interaction
Rhodopsin photocycle
Photoaffinity labelling
Chromophore confirmation in Rh
Transient 'dark activity' of 13-des-Me-retinal
Retinoids that form pigments
Photoaffinity study of rhodopsin: G-protein (transducin) interaction
Age-related macular degeneration
Age pigments or RPE lipofuscin
A2E flurophore
ATP binding cassette protein
Bilberry extract vs. blue-light induced A2E epoxidation

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Series:

Chemical Biology

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Therapeutic Areas:

Ophthalmology

Talk Citation

Nakanishi, K. (2008, August 14). Bioorganic studies of vision [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved June 15, 2025, from https://doi.org/10.69645/YKFO4610.
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