• Structure of the blood-brain barrier
• 36 min
  1. The blood-brain barrier in Alzheimer’s disease

  • Dr. Anika Hartz
• 35 min
  2. Tanycytes allow a tight BBB in the median eminence

  • Prof. Esteban Rodriguez
  • Dr. Juan Luis Blazquez
  • Dr. Montserrat Guerra
• Nutrient transport
• 35 min
  3. Blood-brain barrier ion transport

  • Prof. Martha O'Donnell
• Peptides and proteins
• 37 min
  4. Ingestive peptides

  • Prof. William Banks
• 62 min
  5. Blood-brain barrier in health and disease

  • Prof. Thomas Davis
• Overcoming the blood-brain barrier obstacle
• 42 min
  6. Expression vs. function of ABC transporters at the blood-brain barrier

  • Prof. Jean-Michel Scherrmann
• 44 min
  7. The blood-brain barrier and CNS drug development

  • Dr. Danica Stanimirovic
• 34 min
  8. Transport and delivery of neurotrophic peptides and proteins across the BBB

  • Prof. Weihong Pan
• Diseases involving the blood-brain barrier
• 71 min
  9. Inflammation and immune cell entry to the central nervous system

  • Prof. Serge Rivest
• 42 min
  10. The blood-brain barrier in multiple sclerosis: a target for treatment?

  • Dr. Elga de Vries
• 24 min
  11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development

  • Prof. Ryszard Pluta
• Latest Developments in the Field
• 31 min
  12. MRI approaches for neurovascular imaging

  • Dr. Rick Dijkhuizen
• 33 min
  13. Brain-gut interactions in obesity 1

  • Prof. Weihong Pan
• 19 min
  14. Brain-gut interactions in obesity 2

  • Prof. Weihong Pan
• Archived Lectures *These may not cover the latest advances in the field
• 36 min
  15. Neurotrophins and the BBB

  • Prof. Weihong Pan
• 52 min
  16. Vasoactive peptides and the blood-brain barrier

  • Prof. Maria Deli
  • Prof. Bela Kis
• 42 min
  17. In vivo systems

  • Prof. Quentin Smith
• 46 min
  18. CNS-drug design

  • Prof. Quentin Smith
• 43 min
  19. Brain-to-blood efflux transport of endogenous compounds and its analogue drug at the blood-brain barrier

  • Prof. Tetsuya Terasaki
• 23 min
  20. Stroke and the BBB

  • Prof. Marilyn Cipolla
• 54 min
  21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings

  • Prof. Norman Saunders
• 57 min
  22. Barrier mechanisms in the developing brain: protection or vulnerability?

  • Prof. Norman Saunders
• 43 min
  23. In vitro models of the blood-brain barrier

  • Prof. Pierre-Olivier Couraud
• 41 min
  24. Glucose transport across the blood-brain barrier

  • Prof. Luc Leybaert
• 53 min
  25. The blood-brain barrier and brain tumors

  • Dr. Olaf van Tellingen
• 37 min
  26. Cellular composition of the blood-brain barrier

  • Prof. N. Joan Abbott
• 48 min
  27. Features of mammalian CNS barrier systems

  • Prof. Conrad Johanson

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Ischemic stroke
3. Hypoxia-ischemia brain injury
4. Loss of ATP and brain function
5. Cytotoxic edema
6. Aquaporins and cerebral edema during stroke
7. Role of astrocytes during ischemia
8. Brain edema during stroke: vasogenic
9. Morphologic features of BBB
10. BBB and cerbral endothelial cell transport pathway
11. Altered BBB morphologic features during ischemia
12. Role of actin in BBB permeability regulation
13. Mediators of cerebral edema
14. Reperfusion injury
15. Role of ROS in ischemic brain injury
16. ROS and reperfusion injury
17. Oxidative damage during hypoxia-ischemia injury
18. Oxidative damage during reperfusion injury
19. Antioxidant defense systems
20. SOD in stroke
21. Hemodynamic changes and BBB permeability
22. Hydrostatic brain edema
23. Hemorrhagic transformation
24. Tissue plasminogen activator
25. tPA and BBB disruption in stroke
26. Hyperglycemic stroke and the BBB
27. Summary
28. Acknowledgements

Topics Covered

• Ischemic brain injury
• Cytotoxic and vasogenic brain edema
• Role of BBB in brain edema during stroke
• Cellular regulation of BBB permeability
• Reperfusion injury
• Oxidative damage
• Aquaporins and brain edema
• Mediators of brain edema
• Hemodynamic change during stroke

Links

Series:

• The Blood-Brain Barrier

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on March 1, 2008
• Archived on May 31, 2018

Financial Disclosures

• Prof. Marilyn Cipolla has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.