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- Structure of the blood-brain barrier
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1. The blood-brain barrier in Alzheimer’s disease
- Dr. Anika Hartz
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2. Tanycytes allow a tight BBB in the median eminence
- Prof. Esteban Rodriguez
- Dr. Juan Luis Blazquez
- Dr. Montserrat Guerra
- Nutrient transport
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3. Blood-brain barrier ion transport
- Prof. Martha O'Donnell
- Peptides and proteins
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4. Ingestive peptides
- Prof. William Banks
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5. Blood-brain barrier in health and disease
- Prof. Thomas Davis
- Overcoming the blood-brain barrier obstacle
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6. Expression vs. function of ABC transporters at the blood-brain barrier
- Prof. Jean-Michel Scherrmann
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7. The blood-brain barrier and CNS drug development
- Dr. Danica Stanimirovic
- Diseases involving the blood-brain barrier
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9. Inflammation and immune cell entry to the central nervous system
- Prof. Serge Rivest
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11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development
- Prof. Ryszard Pluta
- Latest Developments in the Field
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12. MRI approaches for neurovascular imaging
- Dr. Rick Dijkhuizen
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13. Brain-gut interactions in obesity 1
- Prof. Weihong Pan
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14. Brain-gut interactions in obesity 2
- Prof. Weihong Pan
- Archived Lectures *These may not cover the latest advances in the field
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15. Neurotrophins and the BBB
- Prof. Weihong Pan
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16. Vasoactive peptides and the blood-brain barrier
- Prof. Maria Deli
- Prof. Bela Kis
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17. In vivo systems
- Prof. Quentin Smith
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18. CNS-drug design
- Prof. Quentin Smith
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20. Stroke and the BBB
- Prof. Marilyn Cipolla
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21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings
- Prof. Norman Saunders
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22. Barrier mechanisms in the developing brain: protection or vulnerability?
- Prof. Norman Saunders
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23. In vitro models of the blood-brain barrier
- Prof. Pierre-Olivier Couraud
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24. Glucose transport across the blood-brain barrier
- Prof. Luc Leybaert
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25. The blood-brain barrier and brain tumors
- Dr. Olaf van Tellingen
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26. Cellular composition of the blood-brain barrier
- Prof. N. Joan Abbott
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27. Features of mammalian CNS barrier systems
- Prof. Conrad Johanson
Printable Handouts
Navigable Slide Index
- Introduction
- Ischemic stroke
- Hypoxia-ischemia brain injury
- Loss of ATP and brain function
- Cytotoxic edema
- Aquaporins and cerebral edema during stroke
- Role of astrocytes during ischemia
- Brain edema during stroke: vasogenic
- Morphologic features of BBB
- BBB and cerbral endothelial cell transport pathway
- Altered BBB morphologic features during ischemia
- Role of actin in BBB permeability regulation
- Mediators of cerebral edema
- Reperfusion injury
- Role of ROS in ischemic brain injury
- ROS and reperfusion injury
- Oxidative damage during hypoxia-ischemia injury
- Oxidative damage during reperfusion injury
- Antioxidant defense systems
- SOD in stroke
- Hemodynamic changes and BBB permeability
- Hydrostatic brain edema
- Hemorrhagic transformation
- Tissue plasminogen activator
- tPA and BBB disruption in stroke
- Hyperglycemic stroke and the BBB
- Summary
- Acknowledgements
Topics Covered
- Ischemic brain injury
- Cytotoxic and vasogenic brain edema
- Role of BBB in brain edema during stroke
- Cellular regulation of BBB permeability
- Reperfusion injury
- Oxidative damage
- Aquaporins and brain edema
- Mediators of brain edema
- Hemodynamic change during stroke
Links
Series:
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Talk Citation
Cipolla, M. (2008, March 1). Stroke and the BBB [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/RCRP6315.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Marilyn Cipolla has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.