• Structure of the blood-brain barrier
• 36 min
  1. The blood-brain barrier in Alzheimer’s disease

  • Dr. Anika Hartz
• 35 min
  2. Tanycytes allow a tight BBB in the median eminence

  • Prof. Esteban Rodriguez
  • Dr. Juan Luis Blazquez
  • Dr. Montserrat Guerra
• Nutrient transport
• 35 min
  3. Blood-brain barrier ion transport

  • Prof. Martha O'Donnell
• Peptides and proteins
• 37 min
  4. Ingestive peptides

  • Prof. William Banks
• 62 min
  5. Blood-brain barrier in health and disease

  • Prof. Thomas Davis
• Overcoming the blood-brain barrier obstacle
• 42 min
  6. Expression vs. function of ABC transporters at the blood-brain barrier

  • Prof. Jean-Michel Scherrmann
• 44 min
  7. The blood-brain barrier and CNS drug development

  • Dr. Danica Stanimirovic
• 34 min
  8. Transport and delivery of neurotrophic peptides and proteins across the BBB

  • Prof. Weihong Pan
• Diseases involving the blood-brain barrier
• 71 min
  9. Inflammation and immune cell entry to the central nervous system

  • Prof. Serge Rivest
• 42 min
  10. The blood-brain barrier in multiple sclerosis: a target for treatment?

  • Dr. Elga de Vries
• 24 min
  11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development

  • Prof. Ryszard Pluta
• Latest Developments in the Field
• 31 min
  12. MRI approaches for neurovascular imaging

  • Dr. Rick Dijkhuizen
• 33 min
  13. Brain-gut interactions in obesity 1

  • Prof. Weihong Pan
• 19 min
  14. Brain-gut interactions in obesity 2

  • Prof. Weihong Pan
• Archived Lectures *These may not cover the latest advances in the field
• 36 min
  15. Neurotrophins and the BBB

  • Prof. Weihong Pan
• 52 min
  16. Vasoactive peptides and the blood-brain barrier

  • Prof. Maria Deli
  • Prof. Bela Kis
• 42 min
  17. In vivo systems

  • Prof. Quentin Smith
• 46 min
  18. CNS-drug design

  • Prof. Quentin Smith
• 43 min
  19. Brain-to-blood efflux transport of endogenous compounds and its analogue drug at the blood-brain barrier

  • Prof. Tetsuya Terasaki
• 23 min
  20. Stroke and the BBB

  • Prof. Marilyn Cipolla
• 54 min
  21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings

  • Prof. Norman Saunders
• 57 min
  22. Barrier mechanisms in the developing brain: protection or vulnerability?

  • Prof. Norman Saunders
• 43 min
  23. In vitro models of the blood-brain barrier

  • Prof. Pierre-Olivier Couraud
• 41 min
  24. Glucose transport across the blood-brain barrier

  • Prof. Luc Leybaert
• 53 min
  25. The blood-brain barrier and brain tumors

  • Dr. Olaf van Tellingen
• 37 min
  26. Cellular composition of the blood-brain barrier

  • Prof. N. Joan Abbott
• 48 min
  27. Features of mammalian CNS barrier systems

  • Prof. Conrad Johanson

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Talk introduction
3. Main aim
4. Methods
5. Experimental protocol
6. Steps of cardiac arrest production
7. Rats electrocardiogram
8. Changes in average heart rate
9. Rats electrocorticogram
10. Results
11. Short-term survival
12. Section reacted for horseradish peroxidase
13. High magnification of leaking vessels
14. Platelets and red cells blocking vessel
15. Horseradish peroxidase extravasations
16. HRP extravasationts into extracellular space
17. Platelets pathology in short-term survival animals
18. Platelets pathology in brain ischemia
19. C-terminal of amyloid precursor immunoreactivity
20. Immunoreactivity for beta-amyloid peptide
21. N-terminal of amyloid precursor immunoreactivity
22. Long-term survival
23. BBB permeability in animals with long-term survival
24. BBB changes in white matter of animals
25. Large platelet aggregate inside blood vessel
26. Two occluded vascular branches
27. Occluded vessel bifurcation
28. Amyloid precursor protein positive material (1)
29. Extra cellular amyloid precursor protein deposits
30. Amyloid precursor protein positive material (2)
31. Extra cellular amyloid precursor protein deposits
32. High magnification of vessel
33. Verifection of white matter in vicinity of vessels
34. Beta-amyloid peptide immunoreactivity
35. Beta-amyloid peptide plaque-like deposits
36. Evidence of beta-amyloid peptide circulatory origin
37. Experimental procedures - group 1
38. Experimental procedures - group 2
39. Observations (1)
40. Observations (2)
41. Observations (3)
42. Observations (4)
43. Observations (5)
44. Scheme of ischemic amyloid plaques development
45. Conclusion
46. Acknowledgements
47. References

Topics Covered

• Ischemic blood-brain barrier involved in Alzheimer's amyloid plaques development and full-blown Alzheimer's disease
• Brain ischemia starts Alzheimer's disease
• Association and risk factors for Alzheimer's disease
• Ischemic mechanisms in Alzheimer's disease in general

Links

Series:

• The Blood-Brain Barrier

Categories:

• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on March 1, 2008

Financial Disclosures

• Prof. Ryszard Pluta has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.