• Structure of the blood-brain barrier
• 36 min
  1. The blood-brain barrier in Alzheimer’s disease

  • Dr. Anika Hartz
• 35 min
  2. Tanycytes allow a tight BBB in the median eminence

  • Prof. Esteban Rodriguez
  • Dr. Juan Luis Blazquez
  • Dr. Montserrat Guerra
• Nutrient transport
• 35 min
  3. Blood-brain barrier ion transport

  • Prof. Martha O'Donnell
• Peptides and proteins
• 37 min
  4. Ingestive peptides

  • Prof. William Banks
• 62 min
  5. Blood-brain barrier in health and disease

  • Prof. Thomas Davis
• Overcoming the blood-brain barrier obstacle
• 42 min
  6. Expression vs. function of ABC transporters at the blood-brain barrier

  • Prof. Jean-Michel Scherrmann
• 44 min
  7. The blood-brain barrier and CNS drug development

  • Dr. Danica Stanimirovic
• 34 min
  8. Transport and delivery of neurotrophic peptides and proteins across the BBB

  • Prof. Weihong Pan
• Diseases involving the blood-brain barrier
• 71 min
  9. Inflammation and immune cell entry to the central nervous system

  • Prof. Serge Rivest
• 42 min
  10. The blood-brain barrier in multiple sclerosis: a target for treatment?

  • Dr. Elga de Vries
• 24 min
  11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development

  • Prof. Ryszard Pluta
• Latest Developments in the Field
• 31 min
  12. MRI approaches for neurovascular imaging

  • Dr. Rick Dijkhuizen
• 33 min
  13. Brain-gut interactions in obesity 1

  • Prof. Weihong Pan
• 19 min
  14. Brain-gut interactions in obesity 2

  • Prof. Weihong Pan
• Archived Lectures *These may not cover the latest advances in the field
• 36 min
  15. Neurotrophins and the BBB

  • Prof. Weihong Pan
• 52 min
  16. Vasoactive peptides and the blood-brain barrier

  • Prof. Maria Deli
  • Prof. Bela Kis
• 42 min
  17. In vivo systems

  • Prof. Quentin Smith
• 46 min
  18. CNS-drug design

  • Prof. Quentin Smith
• 43 min
  19. Brain-to-blood efflux transport of endogenous compounds and its analogue drug at the blood-brain barrier

  • Prof. Tetsuya Terasaki
• 23 min
  20. Stroke and the BBB

  • Prof. Marilyn Cipolla
• 54 min
  21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings

  • Prof. Norman Saunders
• 57 min
  22. Barrier mechanisms in the developing brain: protection or vulnerability?

  • Prof. Norman Saunders
• 43 min
  23. In vitro models of the blood-brain barrier

  • Prof. Pierre-Olivier Couraud
• 41 min
  24. Glucose transport across the blood-brain barrier

  • Prof. Luc Leybaert
• 53 min
  25. The blood-brain barrier and brain tumors

  • Dr. Olaf van Tellingen
• 37 min
  26. Cellular composition of the blood-brain barrier

  • Prof. N. Joan Abbott
• 48 min
  27. Features of mammalian CNS barrier systems

  • Prof. Conrad Johanson

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Outline
3. Neurotrophins and their receptors
4. Characteristics of neurotrophins
5. Neurotrophin receptors and signals
6. Other neurotrophic proteins
7. Neurotrophic peptides (naturally occurring)
8. Neurotrophic support to the brain and spinal cord
9. Blood-brain barrier and blood-spinal cord barrier
10. Characteristics of the blood-brain barrier
11. NGF 30 minutes after iv injection
12. Comparison of neurotrophins kinetic data
13. Octanol/PBS partition coefficient
14. Capillary depletion 10 minutes after iv
15. Saturable transport of NGF
16. Saturable transport of NT3
17. BDNF 60 minutes after iv
18. BDNF entering brain parenchyma
19. Saturable transport of BDNF
20. Efflux of BDNF
21. Classical neurotrophins
22. GDNF 30 minutes after iv administration
23. Influx of GDNF
24. GDNF is relatively stable in circulation
25. Influx transport of CNTF
26. CNTF degradation assay
27. CNTF - conclusion
28. LIF
29. LIF mainly shows reversible vascular binding
30. LIF influx is a saturable process
31. Kinetics of LIF influx in the spinal cord
32. Examination of LIF influx by in situ brain perfusion
33. Blocking antibody, but not CNTF, inhibits LIF influx
34. LIF: no efflux transport
35. Growth hormone: lack of saturable transport
36. In situ brain perfusion data for the growth hormone
37. Growth hormone: uptake by brain parenchyma
38. Co-injection of insulin and growth hormone
39. Insulin does not interfere with IGF1 transport
40. Inhibition of IGF-1 transport by insulin
41. EGF: example of a neurotrophic peptide
42. Recovery of EGF from brain after iv administration
43. EGF distribution between brain and blood
44. TGFalpha shares the transport system with EGF
45. Anti-EGFR Ab showed no effect on EGF influx
46. EGFR knock-out mice maintain transport function
47. There is no efflux transport system for EGF
48. Enhancing CNS delivery of peptides and proteins
49. BBB-targeting of BDNF in rats
50. Neuroprotective effect of bFGF/OX26-SA conjugate
51. Application of a BBB-penetrating form of GDNF
52. Effects of IGF-I intranasal administration
53. Left forepaw-placing test
54. Vestibulomotor function in the beam balance test
55. BDNF gene delivery into the CNS
56. BDNF levels in transplanted mouse brain cells
57. Limitations
58. Other means for neuroprotection and regeneration
59. Summary
60. References

Topics Covered

• Overview of neurotrophins
• CNS physiology and roles in neuroregeneration
• The blood-brain barrier (BBB)
• General strategies to enhance CNS delivery
• Progress on neurotrophin delivery across the BBB
• Limitations and future directions

Links

Series:

• The Blood-Brain Barrier

Categories:

• Neuroscience
• Pharmaceutical Sciences

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on March 1, 2008
• Archived on January 31, 2017

Financial Disclosures

• Professor Weihong Pan has no commercial/financial relationships to disclose