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- Structure of the blood-brain barrier
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1. The blood-brain barrier in Alzheimer’s disease
- Dr. Anika Hartz
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2. Tanycytes allow a tight BBB in the median eminence
- Prof. Esteban Rodriguez
- Dr. Juan Luis Blazquez
- Dr. Montserrat Guerra
- Nutrient transport
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3. Blood-brain barrier ion transport
- Prof. Martha O'Donnell
- Peptides and proteins
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4. Ingestive peptides
- Prof. William Banks
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5. Blood-brain barrier in health and disease
- Prof. Thomas Davis
- Overcoming the blood-brain barrier obstacle
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6. Expression vs. function of ABC transporters at the blood-brain barrier
- Prof. Jean-Michel Scherrmann
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7. The blood-brain barrier and CNS drug development
- Dr. Danica Stanimirovic
- Diseases involving the blood-brain barrier
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9. Inflammation and immune cell entry to the central nervous system
- Prof. Serge Rivest
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11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development
- Prof. Ryszard Pluta
- Latest Developments in the Field
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12. MRI approaches for neurovascular imaging
- Dr. Rick Dijkhuizen
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13. Brain-gut interactions in obesity 1
- Prof. Weihong Pan
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14. Brain-gut interactions in obesity 2
- Prof. Weihong Pan
- Archived Lectures *These may not cover the latest advances in the field
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15. Neurotrophins and the BBB
- Prof. Weihong Pan
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16. Vasoactive peptides and the blood-brain barrier
- Prof. Maria Deli
- Prof. Bela Kis
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17. In vivo systems
- Prof. Quentin Smith
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18. CNS-drug design
- Prof. Quentin Smith
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20. Stroke and the BBB
- Prof. Marilyn Cipolla
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21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings
- Prof. Norman Saunders
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22. Barrier mechanisms in the developing brain: protection or vulnerability?
- Prof. Norman Saunders
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23. In vitro models of the blood-brain barrier
- Prof. Pierre-Olivier Couraud
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24. Glucose transport across the blood-brain barrier
- Prof. Luc Leybaert
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25. The blood-brain barrier and brain tumors
- Dr. Olaf van Tellingen
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26. Cellular composition of the blood-brain barrier
- Prof. N. Joan Abbott
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27. Features of mammalian CNS barrier systems
- Prof. Conrad Johanson
Printable Handouts
Navigable Slide Index
- Introduction
- BBB is an impediment in CNS drug development
- CNS drug development
- The evolving concept of the blood-brain barrier
- Neurovascular unit as an integrated concept
- Tight junctions form the 'physical' barrier
- The transport systems of the blood-brain barrier
- Strategies to deliver drugs into the brain (1)
- Strategies to deliver drugs into the brain (2)
- Strategies to deliver drugs into the brain (3)
- Routes for drug delivery across the BBB
- Transcellular lipophilic diffusion
- Inhibition of efflux pumps
- Paracellular hydrophilic diffusion
- Carrier-mediated transport
- Adsorptive endocytosis
- Receptor-mediated transcytosis
- The molecular 'Trojan horses' concept
- 'Trojan horses'
- HIR as a 'Trojan horse' for drug delivery to the brain
- 'Trojan horses' and nanocarriers
- Considerations in designing 'Trojan horses'
- Discovery and development of novel 'Trojan horses'
- Single domain antibodies
- Single-domain antibody phage display libraries
- Selection of the BBB - targeting sdAbs
- Brain-targeting single-domain antibodies
- Mechanisms of transport
- Linking molecules to FC5
- In vivo biodistribution of FC5
- Improving FC5 pharmacokinetics
- Brain accumulation of FC5 formulations
- Detection of FC5 in brain tissues
- Detection of FC5 by confocal microscopy (1)
- Detection of FC5 by confocal microscopy (2)
- Summary
- FC5-functionalized liposomes
- Delivery using FC5-functionalized liposomes (1)
- Delivery using FC5-functionalized liposomes (2)
- Tailoring BBB delivery strategies (1)
- Tailoring BBB delivery strategies (2)
Topics Covered
- Restrictive nature of the blood-brain barrier
- Non-vascular routes for brain drug delivery
- Vascular routes for brain drug delivery
- Concept of Trojan horses
- Discovery of novel receptor-mediated transcytosis routes across the blood-brain barrier
- Principles of blood-brain barrier vector development in experimental models
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Stanimirovic, D. (2008, March 1). The blood-brain barrier and CNS drug development [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 8, 2024, from https://doi.org/10.69645/GGED9050.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Danica Stanimirovic has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.